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Organic Chemistry

Tutor Ing. Petr Beier, Ph.D.
Team Petr Beier
Topic Fluoroalkylated hypervalent iodine compounds for thiol bioconjugations

Fluorinated hypervalent iodine compounds such as Togni reagents have become widely used electrophilic trifluoromethylating reagents.1 They display a unique reactivity profile and functional group compatibility. Recently, in our group we have prepared substituted tetrafluoroethylene-containing reagents and have shown their application in reactions with various nucleophiles.2 In this project, we aim to synthetize fluoroalkylated hypervalent iodine reagents bearing a functional group and investigate their utilization in tagging biological thiols. New approaches to highly selective thiol bioconjugation are of great interest to biochemists.

Key references:
1. J. Charpentier, A. Togni, et al. Chem. Rev. 2015, 115, 650.
2. V. Matousek, P. Beier, et al. Chem. Eur. J. 2016, 22, 417.