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Organic Chemistry

Tutor Ing. Petr Beier, Ph.D.
Team Petr Beier
Topic Synthesis and reactivity of perfluoroalkyl azides and other N-perfluoroalkylated compounds

Organic azides are valuable intermediates in organic synthesis. We have recently reported efficient and scalable synthesis of CF3N3 and other perfluoroalkyl azides. Application of these useful but so far poorly studied fluorinated synthons in copper-catalyzed azide-alkyne cycloaddition provided novel N-perfluoroalkyl triazoles. In this project the rich chemistry of perfluoroalkyl azides will be investigated and new synthetic approaches to underdeveloped N-perfluoroalkyl-containing compounds will be studied. This class of compounds is expected to find utilization in drug discovery and in the development of new materials.

Key references:
1. Z. E. Blastik, P. Beier, et al. Angew. Chem. Int. Ed. doi: 10.1002/anie.201609715.
2. A. Budinská, P. Beier, et al. Org. Lett. 2016, 18, 5844.