HomePhD Study at IOCBTopics 2018Organic Chemistry

Organic Chemistry

Tutor Ing. Petr Beier, Ph.D.
Team Petr Beier
Topic Synthesis and application of N-fluoroalkylated compounds
Faculty FCHT VŠCHT, PřF UK
Abstract

The recently reported synthesis of perfluoroalkyl azides1 opened the door to study properties and reactivity of these compounds. In this project, the rich chemistry of (per)fluoroalkyl azides1-3 will be investigated and new synthetic approaches to underdeveloped N-fluoroalkyl-containing compounds such as azides, azoles, ureas, carbamates, and amides will be studied. This class of compounds is expected to find utilization in drug discovery and in the development of new materials.

Key references:
1. Z. E. Blastik, P. Beier, et al. Angew. Chem. Int. Ed. 2017, 56, 346.
2. A. Budinská, P. Beier, et al. Org. Lett. 2016, 18, 5844.
3. S. Voltrová, P. Beier, et al. Org. Biomol. Chem. 2017, 15, 4962.