HomePh.D. Study at IOCBArchive - 2018Organic Chemistry

Organic Chemistry

Tutor Dr. habil. Ullrich Jahn
Team Ullrich Jahn
Topic Tandem Organometallic Conjugate Addition/Cycloaddition Processes for Syntheses of Constrained Amino Acids and Their Applications in the Synthesis of Peptides and Natural Products
Faculty FCHT / FPBT VŠCHT, PřF UK
Abstract

In this project, conceptually new tandem processes consisting of asymmetric conjugate addition reactions and 1,3-dipolar cycloadditions will be developed. This methodology will allow a one-step access to functionalized saturated cyclic amino acid derivatives. Their potential toward the synthesis of modified peptides and the total synthesis of biologically active pyrrole-imidazole alkaloids, such as Massadine, will be explored.