HomePh.D. Study at IOCBTopics 2019Biochemistry and Molecular Biology

Biochemistry and Molecular Biology

Tutor Václav Veverka, Ph.D.
Team

Pavlína Řezáčová

Topic Targeting hematological malignancies using fragment-based drug design
Faculty PřF UK
Abstract

The project will be focused on the knowledge-based design of active compounds targeting several proteins or protein-protein interactions, which are implicated in the development of hematological malignancies. The compounds will be developed using the fragment-based approach. The work on this project provides the opportunity to acquire an expertise in protein biochemistry, biophysics and structural biology, as well as to get an insight into the rational drug design process through a close collaboration with the medicinal and computational chemists.

Leading references:
1. Hnizda, A., et al.,Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation. Leukemia 2018, 32 (6), 1393.
2. Čermáková, K., et al., Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia. Cancer Research, 2014. 74 (18): 5139