HomePh.D. Study at IOCBTopics 2019Biochemistry and Molecular Biology

Biochemistry and Molecular Biology

Tutor Václav Veverka, Ph.D.

Pavlína Řezáčová

Topic Transient nuclear protein-protein interaction networks
Faculty PřF UK

Many processes implicated in the regulation of DNA transcription are driven by highly modular protein-protein interaction networks that are not exclusively maintained by the well structured protein domains but also by highly dynamic regions of interacting proteins. The aim of the doctoral project will be an identification as well as investigation of the physiological and pathological roles of these transient interactions using highly interdisciplinary approach, including  protein biochemistry, biophysics, cell  and structural biology.

Leading references:
1. Sharma, S., et al., Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation. Proc Natl Acad Sci U S A, 2014. 115 (30): E7053
2. Těšina, P., et al., Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif. Nature Communications, 2015. 6: 7968