Light Control of Biomolecular Processes

Mini-symposium on new insights about how biological systems can be controlled with light. This traceless reagent enables a vast scope of possibilities to elucidate the yet undiscovered facets of nature. Photoactivatable compounds such as one- and two-photon cages, molecular switches and activatable fluorophores and sensors represent important tool for studying and control of biologically relevant processes, such as transcription, translation, protein and DNA folding and biological signalling.


8:50 – 9:00    Invitation and opening remarks (Tomáš SLANINA & Zdeněk HOSTOMSKÝ)
9:00 – 9:45    Plenary talk
Alexander HECKEL
Shedding Light on Nucleic Acids
Research Topic 1: Cages and Switches
09:45 – 10:05    Nikolai GREBENOVSKY    Amphidynamic Materials as Molecular Machines
10:05 – 10:25    Volker HERMANNS    Extending the Photochemical Toolbox
10:25 – 10:45    Janik KAUFMANN    Development of BODIPY-Based Light-Inducible Antisense Oligonucleotides for RNA Processing in Plants
10:45 – 11:05    Coffee break
Research Topic 2: RNA Control
11:05 – 11:25    Patricia MÜLLER    Development of Light-Inducible AntimiRs as Therapeutic Agents
11:25 – 11:45    Robin KLIMEK    Regulation of Non-Coding RNA in Neurons
11:45 – 12:05    Anja BLÜMLER    Chemo-Enzymatic Synthesis of Modified RNA
12:05 – 13:30    Lunch break and discussions
Research Topic 3: Bioorganic Chemistry of Nucleic Acids
13:30 – 14:15    Plenary talk
Michal HOCEK
Modified nucleic acids for diagnostics and chemical biology
14:15 – 14:35    Zuzana VANÍKOVÁ    Switching of enzymatic cleavage of DNA and transcription through photocaging, deprotection and phosphorylation reactions on DNA
Research Topic 4: 2-Photon Activation
14:35 – 14:55    Yvonne BECKER    New Two-Photon Caging Groups and Excitation-Specific Photochemistry
14:55 – 15:15    Rebekka WEBER    Enhanced Two-Photon Uncaging via Intramolecular FRET
15:15 – 15:30    Coffee break
15:30 – 15:50    Tomáš SLANINA    Catch-And-Release: More then bioconjugations
15:50 – 16:35    Plenary talk
Bioorthogonal chemistry of heterodienes: Application in bioimaging and beyond
16:35 – 16:40    Closing remarks (Tomáš SLANINA)

Photos from the Minisymposium for download (3000×2000px adjusted jpeg; zip file)