Profil

Vzdělání
Od 2018

PhD Student (Organická syntéza), Faculty of Science, Charles University in Prague.
PhD thesis: Synthesis of steroidal modulators for TGR5 membrane receptor. (supervisor: RNDr. Eva Kudová, Ph.D.)

Nejnovější publikace

When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists
ChemMedChem 18 (4): e202200556 (2023)
Selectivity of Oxidizing Agents toward Axial and Equatorial Hydroxyl Groups
Journal of Organic Chemistry 87 (14): 9157–9170 (2022)
(E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimulating Glucagon-like Peptide-1 Secretion From Enteroendocrine Cells
Frontiers in Pharmacology 12: 713149 (2021)
3β-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolism
Journal of Steroid Biochemistry and Molecular Biology 202: 105702 (2020)