Zvaná přednáška – F. Ulrich Hartl
Prof. F. Ulrich Hartl (Max Planck Institute of Biochemistry, Martinsried, Německo)
Molecular Chaperones in Protein Folding and Proteostasis
3. dubna 2023, 10:00
Přednáškový sál ÚOCHB
The past two decades have witnessed a paradigm shift in our understanding of cellular protein folding. While the three-dimensional structures of functional proteins are determined by their amino acid sequences, we now know that in the crowded environment of cells, newly-synthesized polypeptides depend on molecular chaperone proteins to reach their folded states efficiently and at a biologically relevant time scale. Assistance of protein folding is provided by different types of chaperones which act to prevent misfolding and aggregation, often in an ATP-dependent mechanism. Once folded, many proteins continue to require chaperone surveillance to retain their functional states, especially under conditions of cell stress. Failure of the chaperone machinery to maintain proteostasis, i.e. the conformational integrity and balance of the cellular proteome, facilitates the manifestation of diseases in which proteins misfold and form toxic aggregates. These disorders include Parkinson’s, Huntington’s and Alzheimer’s disease.
I will provide an overview of chaperone functions in protein folding and then discuss recent work providing new insights in the role of chaperones in proteostasis maintenance.