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Míra is our only PhD student. He is studying Organic chemistry at Faculty of Science at Charles University. He works on IOCB since 2014, when he started his Master thesis here. His current project is synthesis of ligands for Farnesoid and The bile acid G-coupled receptors. These receptors can be used to treat such diseases as Primary biliary cholangitis (PBC) or Non-alcoholic fatty liver disease (NAFLD). There are also publications suggesting connection between these receptors and diabetes type 2.
Mgr. Miroslav Kašpar
Profile
Education
Since 2018
PhD Student (Organic Synthesis), Faculty of Science, Charles University in Prague.
PhD thesis: Synthesis of steroidal modulators for TGR5 membrane receptor. (supervisor: RNDr. Eva Kudová, Ph.D.)
Latest publications
When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists
ChemMedChem 18 (4): e202200556 (2023)
Selectivity of Oxidizing Agents toward Axial and Equatorial Hydroxyl Groups
Journal of Organic Chemistry 87 (14): 9157–9170 (2022)
(E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimulating Glucagon-like Peptide-1 Secretion From Enteroendocrine Cells
Frontiers in Pharmacology 12: 713149 (2021)
3β-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolism
Journal of Steroid Biochemistry and Molecular Biology 202: 105702 (2020)