Recent papers

The Rhomboid Superfamily: Structural Mechanisms and Chemical Biology Opportunities
Trends in Biochemical Sciences 43 (9): 726-739 (2018)
Benzoxazin-4-ones as novel, easily accessible inhibitors for rhomboid proteases
J. Yang
M. Barniol-Xicota
M. T. N. Nguyen
A. Tichá K. Stříšovský
S. H. L. Verhelst
Bioorganic and Medicinal Chemistry Letters 28 (8): 1423-1427 (2018)
Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors
P. Goel
T. Jumpertz
A. Tichá
I. Ogorek
D. C. Mikles M. Hubálek
C. U. Pietrzik
K. Stříšovský
B. Schmidt
S. Weggen
Bioorganic and Medicinal Chemistry Letters 28 (8): 1417-1422 (2018)
Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases
P. Goel
T. Jumpertz
D. C. Mikles A. Tichá
M. T. N. Nguyen
S. Verhelst
M. Hubálek
D. C. Johnson
D. A. Bachovchin
I. Ogorek
C. U. Pietrzik
K. Stříšovský
B. Schmidt
S. Weggen
Biochemistry 56 (51): 6713-6725 (2017)