PhD project

Delivery tools for crossing the blood brain barrier

Pavel Šácha
Jan Konvalinka Group
Proteases of Human Pathogens


The glutamate carboxypeptidase II (GCPII) is a metallopeptidase expressed in the brain where it cleaves the most abundant neurotransmitter N-acetylaspartylglutamate to major excitatory neurotransmitter glutamate. The inhibition of GCPII in brain can help in various pathological conditions like stroke, neurodegenerative disease e.g. amyotrophic lateral sclerosis, Parkinson's disease and Huntington's disease. The aim of the project is to deliver potent inhibitor via blood brain barrier, inhibit the GCPII enzyme and help in those pathological conditions. Financial support: This project has support of the Czech Science Foundation grant (GACR).

Field of study: Biochemistry


PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.

How to apply

Please return to the PhD projects at IOCB Prague – Call for Applications 2022 page and follow the instructions.

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