Viral proteases of important human pathogens
Viral proteases are indispensable for successful viral replication and represent also important pathogenic factors. Better understanding of these processes is important for future therapies. The work will focus mainly to proteases from flaviviruses (Zika, Dengue), coronaviruses (SARS-CoV-2) and retroviruses (HIV). The experimental work will include cloning, protein expressions, purifications, biophysical characterizations and crystallizations, handling with small-compounds libraries and biological libraries, tissue culture work and analyses (microscopy, flow cytometry), development and adaptation of enzymological and cell based phenotypic assays. The outputs will help to better understand pathogenesis and possibilities of targeting of viral proteases.
Field of study: Physical chemistry
PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.
How to apply
Please return to the PhD projects at IOCB Prague – Call for Applications 2022 page and follow the instructions.