The polymeric conjugates as an experimental tool in immunomodulation and immunotherapy
The immune system plays a very important role in fighting diseases such as cancer. Manipulating the immune system with monoclonal antibodies against certain cancers have become a routine therapeutic approach. However, their high cost, instability and potential immunogenic side effects have caused researchers to turn their attention to the investigation of peptides and other small-molecules, especially small-molecule inhibitors to design a better approach. Recently developed polymeric conjugates (iBodies) have shown to be potent and promising substitution for the antibodies in analytic and diagnostic biomedical methods. iBodies take the advantage of low-molecular-weight compounds as targeting ligand to overcome the challenges of antibodies. The aim of the doctoral project is to develop mono- and bi-specific iBodies against both immune and tumor cell surface markers in order to increase the efficacy of the immune cell responses against cancer cells.
Field of study: Biochemistry/Immunology
PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.
How to apply
Please return to the PhD projects at IOCB Prague – Call for Applications 2022 page and follow the instructions.