The role of anorexigenic and orexigenic peptides in pathogenesis of obesity and neurodegeneration
Neurodegeneration has been recently linked to disturbed central insulin signaling, leptin resistance, obesity and type 2 diabetes. Interestingly, both anorexigenic peptides, such as prolactin-releasing peptide (PrRP), and orexigenic peptides, such as ghrelin, whose dysregulation is observed in metabolic diseases, were identified as potentially neuroprotective compounds; thus, both compounds could be involved in development of obesity and neurodegeneration. The major aim of this project is to find out if our novel peripherally administered and centrally acting anorexigenic or orexigenic analogs of PrRP and ghrelin have some common beneficial effect on the neurodegenerative changes in brain. Effect of these analogs will be followed in mouse and rat models of obesity and/or neurodegeneration and their wild type controls, where metabolic and neurodegenerative changes together with neuroinflammation and lowered neurogenesis will be monitored. These novel peptidic analogs could have a potential for treatment of mentioned pathologies.
Field of study: Biochemistry/Physiology
PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.
How to apply
Please return to the PhD projects at IOCB Prague – Call for Applications 2022 page and follow the instructions.