PhD project

Modified ribonucleotides for enzymatic synthesis of RNA analogues

Michal Hocek
Michal Hocek Group
Bioorganic and Medicinal Chemistry of Nucleic Acids


We will design and synthesize modified ribonucleoside triphosphates with modified sugar part (e.g. 2'-OMe, 2'-N3 etc.) bearing diverse functional groups at nucleobase. These nucleotides will be used for enzymatic synthesis of modified oligonucleotides (stable analogues of RNA) for applications in RNA interference, CRISPR editing or for studying of translation.

Field of study: Organic chemistry


PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.

How to apply

Please return to the PhD projects at IOCB Prague – Call for Applications 2022 page and follow the instructions.

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