PhD project

New deazapurine nucleosides and prodrugs as potential cytostatics

Michal Hocek
Michal Hocek Group
Bioorganic and Medicinal Chemistry of Nucleic Acids


We will design and synthesize new modified nucleosides and their prodrugs with modified sugar part and nucleobase and will study their biological activity and mechanism of action. Selected active compounds will be further optimized in order to identify preclinical candidates for development of potential antitumor agents.

Field of study: Organic chemistry


PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.

How to apply

Please return to the PhD projects at IOCB Prague – Call for Applications 2022 page and follow the instructions.

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