PhD project

PhD study in bioorganic chemistry at IOCB Prague and Charles University

Michal Hocek
Michal Hocek Group
Bioorganic and Medicinal Chemistry of Nucleic Acids


Two EU-funded PhD studentships are available in Prof. Michal Hocek group starting from September 2020. 

The candidates will join an international multidisciplinary team of the Joint Laboratory of Bioorganic and Medicinal Chemistry of Nucleic Acids of the Institute of Organic Chemistry and Biochemistry (IOCB Prague) of the Czech Academy of Sciences and the Charles University in Prague. 

The project (within a newly awarded International Training Network project NATURE-ETN funded by the EU) will involve the design and synthesis of novel base-modified nucleotides and nucleic acids and their applications in chemical biology (i.e. synthesis of stabilized modified RNA for CRISPR-Cas or chemical detection and pull-down of epigenetic bases in DNA). 

The positions are based at IOCB in Prague but close international collaboration and short stays in collaborating research groups in the UK, Germany, and Poland will be required.


The applicants should hold (or be expected to obtain in 2020) an MSc. degree or an equivalent (in organic, bioorganic or medicinal chemistry or chemical biology) and should have a good theoretical knowledge and practical laboratory experience in organic synthesis, bioorganic chemistry and/or biochemistry and a good command of spoken and written English. 

The candidates should not have spent more than 6 months in the last 3 years in the Czech Republic.

How to apply

Please submit a cover letter, CV, list of publications and contact information for 2 references combined into one PDF file by e-mail to

Applications will be reviewed and considered at any time before the deadline of March 15, 2020 (subject to further formal application to the PhD program of the Charles University and passing the entrance exam). 

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