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Open Positions


Postdoc / Research Associate – screening and diagnostics technology development

  • Are you a talented scientist with experience in biochemistry or molecular biology?
  • Do you want to contribute to the transition of basic research to real world applications?
  • Do you want to be a part of a dynamic team with entrepreneurial atmosphere?

Who we are
We have developed a novel proprietary assay called DIANA, which is suitable for ultrasensitive and selective enzyme detection and inhibitor screening (Navratil et al. 2017 in Nucl. Acids Res.). This multiwell plate based assay utilizing DNA-linked probe for target detection offers several unique advantages over existing approaches both in in vitro diagnostics and in early drug discovery. The commercial applications of the assay are being developed in collaboration with major industrial partners.
We are based in the laboratory of Jan Konvalinka at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences in Prague. We greatly benefit from available expertise and excellent experimental facilities in the institute, which has a global reputation and strong record in drug discovery. We also plan to found a spin-off company in the near future in order to deliver our products to the market.

What responsibilities you will have
In this position, you will be a part of a multidisciplinary team that seeks further development of the DIANA assay for novel targets and for novel applications. You will be expected to deliver closely coordinated specific developmental tasks but you will also drive your independent research projects.
You will employ molecular biology methods, such as qPCR, molecular cloning, western-blotting, enzyme kinetics and multiwell plate based assays, as well as cell culture, protein expression and purification techniques. You will also contribute to protocol automatization and development of the assay to a standardized kit format.
While the main criteria of success is successful introduction of DIANA to diagnostics and screening markets, we also expect that you will author several research publications in high impact journals.

Who you are
You have a doctorate degree or 4 years of equivalent scientific experience in biochemistry, molecular biology or related field. You have experience with PCR, molecular cloning, recombinant protein expression, cell culture and working with antibodies. Experience with immunoassays such as ELISA and/or research background in kinases, methyltransferases or GPCRs is a plus.
You are friendly, enthusiastic, team oriented and skilled person with a strong inner drive. You are organized and able to plan and conduct your work independently and to take responsibility for end-to-end delivery of developmental projects. You are not afraid to work on multiple challenges in parallel and at the same time, you pay attention to details. Your fluent English and strong communication skills enables you to facilitate research collaborations. You are motivated to contribute to the technology development and interested to work on an interface of academic and applied research.

The position is available starting immediately. You will be offered a competitive salary with an initial 1-year contract, which can be later extended for another 1-2 years. You will also get an opportunity to join a newly established company.

We are looking forward to receiving your motivation letter and CV (incl. list of publications and two reference contacts) to vaclav.navratil@uochb.cas.cz.

 



A Ph.D. position in Biochemistry

is offered at the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences in Prague, Czech Republic.


The multidisciplinary project deals with the study on insulin storage forms in pancreatic secretory granules. The project should provide the first insight into the structural forms of insulin present in pancreatic cells and elucidate the role of their endogenous chemical components in regulation of insulin storage, release and physiology. The project should also decipher some strategies for modulation of insulin release from pancreatic beta-cells by small molecule ligands.

The student will work in Jiří Jiráček’s Group, which is engaged in structure-activity studies of insulin and insulin-like growth factors 1 and 2. IOCB Prague is an excellent European institute with state of the art facilities and an international and stimulating atmosphere to accomplish your goals. Prague is an excellent place to live.

Requirements and how to apply:
Motivated candidates must hold a Master degree in the field of molecular biology, biochemistry or organic chemistry. All the applicants should send their CV, motivation letter and contact details of two referees to Dr. Jiří Jiráček (✉: jiracek@uochb.cas.cz). The position is available from September 2017.

 



Postdoc position - IOCB Prague

Job description (Projects):

  • Development of a molecular toolkit for control and investigation of the bacterial stringent response
  • Development of novel antibacterials termed lipophosphonoxins
  • Design and synthesis of azanuceloside phosphonates and -boronates as inhibitors of 6-oxopurine phosphoribosyltransferases and their prodrugs as potential drugs against malaria and tuberculosis.

Requirements:

  • Ph.D. in Organic chemistry (synthesis, separation techniques, characterization – NMR, MS, LC-MS, IR..)
  • English language

Salary: 36 000 CZK (Gross)

Start date: April 2017

Benefits:

  • Employee benefits
  • Extra week of vacation
  • Walking distance from Metro station Dejvická

How to apply: Motivation letter and CV should be sent to Dr. Dominik Rejman (rejman@uochb.cas.cz).

 



Master / Ph.D. student - Ion Channels in Neurological Disorders

The Ion Channels and Diseases lab of Dr. Norbert Weiss (www.theweisslab.com) at the Institute of Organic Chemistry and Biochemistry in Prague, Czech Republic, is looking for a motivated Master/PhD student interested in studying the molecular and cellular basis of neuronal disorders linked to calcium channels. The project involves functional analysis of calcium channel activity in cell lines and primary neurons by patch-clamp electrophysiology, confocal microscopy, in combination with various techniques of molecular biology and biochemistry.

Work in the lab focuses on the molecular physiology of T-type calcium channels, with an emphasis on elucidating the molecular mechanisms and actors controlling their trafficking to the cell surface, in normal and pathological conditions.

The lab is located at the Institute of Organic Chemistry and Biochemistry (www.uochb.cz), which is a leading and interdisciplinary research center with international faculty and students.

Your profile
The position will be available starting as immediately as February 2017 and is open for Master and Ph.D. students in a relevant field (neuroscience, biology), and ideally prior experience in patch clamp electrophysiology. Interested candidates should send their curriculum vitae, a description of their scientific interest and the name and contact information of up to three references who are able to comment on your academic background to weiss@uochb.cas.cz. A good command in English is a requirement. We are looking forward to receiving your application.

 



Research and development specialist/Technician (Dr. F. Teplý group)

Job description:

  • We develop inhibitors of expression of c-myc gene, which is decisive for the majority of oncologic disorders. The inhibitory effect is based on stabilization of secondary structures in the promoter of c-myc gene.
  • The work will include analysis of substances in vitro by polymerase stop method (radioactive version), FRET melting and thermophoresis. Best compounds will be further tested in selected cell lines (toxicity, analysis of the expression level of mRNA and protein).

We offer:

  • Interesting work in interdisciplinary research environment focused at developing new anticancer drug candidates.
  • Work in a young and dynamic international team on the border of medicinal chemistry, biochemistry and pharmacology.
  • Support for continuing education and personal growth (courses).
  • Work contract (full-time employment) for 1 year with possibility of extension for three years.
  • Place of work: IOCB, CAS, Prague 6.

Requirements:

  • University degree (Mgr., Ing., or Bc.) in biochemistry, molecular biology, pharmacology or related field.
  • Reliability, responsibility, flexibility.
  • Willingness to learn new methodological procedures, manual skills, a positive attitude to science and research (internal motivation).
  • Knowledge of English and good computer skills (MS Office).
  • The position is suitable for fresh graduates, laboratory experience is an advantage.

How to apply:

  • Motivation letter and CV should be sent to Dr. Filip Teplý (teply@uochb.cas.cz).
  • Possible start immediately.

 



Postdoctoral position in Biochemistry/Structural Biology: Prague, Czech Republic

We are seeking a highly motivated individual who is willing to accept the challenge of cutting edge research at the interface biochemistry/structural biology of G-quadruplexes.

Job Description: This project is focused mainly at c-myc G-quadruplex and will also involve evaluation of small molecule ligands using techniques of biochemistry/molecular biology. Successful applicant for this postdoc position will be an outstanding self-driven person who will primarily explore the crystallizations of promoter G-quadruplexes with small molecule ligands. The aim is to elucidate molecular details of their interaction. Innovative crystallization approaches will be pursued. Located in the stunning city of Prague, our research facilities comprise a state-of-the-art instrumentation portfolio.

Requirements: Applicant must have Ph.D. in biology, biochemistry or a closely related discipline. The candidates must be a first author on at least 2-3 publications. This position requires prior experience in biochemistry and structural biology techniques. Excellent oral and written communication skills in English are required as well as the ability to conduct independent scientific investigations. Position is for one year with possible extension.

How to apply: Please submit cover letter, CV, and contact information for 2-3 references combined into one PDF file by e-mail to: teply@uochb.cas.cz and rezacova@uochb.cas.cz

Contacts:
Filip Teplý, Ph.D. and Pavlína Řezáčová, Ph.D.
Institute of Organic Chemistry and Biochemistry CAS, v.v.i.
Flemingovo nám. 542/2
166 10 Prague 6
Czech Republic
✉: teply@uochb.cas.cz / rezacova@uochb.cas.cz