IOCB covers 2020

Advanced molecular nanocarbons are now in the spotlight reflecting the basic discoveries of fullerenes, carbon nanotubes, and graphene. Iconic helicenes and their congeners combine a unique π-electron system with helical chirality that makes them highly attractive in various fields of science. (Covert art: Tomáš Belloň / IOCB Prague)

• Article: Stará, I. G.; Starý, I. Helically Chiral Aromatics: The Synthesis of Helicenes by [2 + 2 + 2] Cycloisomerization of π-Electron Systems. Acc. Chem. Res. 2020, 53, 144–158. https://doi.org/10.1021/acs.accounts.9b00364 
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Covert art: Tomáš Belloň / IOCB Prague

• Article: Strmeň, T.; Vrkoslav, V.; Bosáková, Z.; Cvačka, J. Atmospheric pressure chemical ionization mass spectrometry at low flow rates: Importance of ion source housing. Rapid Commun. Mass Sp. 2020, 34, e8722. https://doi.org/10.1002/rcm.8722
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Using solid-state NMR spectroscopy, the cis/trans isomerization in a 2-D array of surface-mounted azobenzene-based switches was detected for the first time. In order to achieve this, a new class of rod-shaped molecular switches was synthesized. The switching of individual molecules is not compromised by the close proximity of neighbors. (Cover art: Tomáš Belloň / IOCB Prague)

• Article: Santos Hurtado, C.; Bastien, G.; Mašát, M.; Štoček, J. R.; Dračínský, M.; Rončević, I.; Císařová, I.; Rogers, C. T.; Kaleta, J. Regular Two-Dimensional Arrays of Surface-Mounted Molecular Switches: Switching Monitored by UV–vis and NMR Spectroscopy.  J. Am. Chem. Soc. 2020, 142, 9337–9351. https://doi.org/10.1021/jacs.0c01753
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Parallel worlds: An artistic parallel between the space-time curvature underlying gravity around a heavy magnetar with its effect on the neighboring objects in the macro world and the relativistic heavy-neighbor-atom effects on NMR shifts across the Periodic Table in the sub-nano world. (Cover art: Tomáš Belloň / IOCB Prague)

• Article: Vı́cha, J.; Novotný, J.; Komorovsky, S.; Straka, M.; Kaupp, M.; Marek, R. Relativistic Heavy-Neighbor-Atom Effects on NMR Shifts: Concepts and Trends Across the Periodic Table. Chem. Rev. 2020, 120, 7065–7103. https://doi.org/10.1021/acs.chemrev.9b00785
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A novel labeled nucleotide exerts very low near-IR fluorescence in water but lights-up (up to a 348-fold increase) after polymerase incorporation to DNA. It can be used to directly visualize enzymatic DNA synthesis in vitro and the labeled DNA probes are also responsive to secondary structure changes or interactions with small molecules or proteins. Its application was demonstrated on real-time PCR detection of RNA from SARS-CoV-2 virus. (Cover art: Tomáš Belloň / IOCB Prague)

• Article: Kuba, M.; Kraus, T.; Pohl, R.; Hocek, M. Nucleotide-Bearing Benzylidene-Tetrahydroxanthylium Near-IR Fluorophore for Sensing DNA Replication, Secondary Structures and Interactions. Chem. Eur. J. 2020, 26, 11950–11954. https://doi.org/10.1002/chem.202003192 
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Cover art: Tomáš Belloň / IOCB Prague

• Article: Gaur, P.; Galkin, M.; Hauke, S.; Redkin, R.; Barnes, C.; Shvadchak, V. V.; Yushchenko, D. A. Reversible spatial and temporal control of lipid signaling. Chem. Commun. 2020, 56, 10646–10649. https://doi.org/10.1039/D0CC04146G
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The Front Cover shows cobalt bis(dicarbollide) alkylsulfonamide, which acts as an inhibitor of carbonic anhydrase IX (CA IX). This enzyme is overexpressed on the cell surface of hypoxic cancer cells, and plays a critical role in cancer cell survival and in the formation of metastases. The inhibition of CA IX is known to result in reduced tumor growth. The new family of potent and selective CA IX inhibitors combines a structural motif of a bulky inorganic cobalt bis(dicarbollide) polyhedral ion with a propylsulfonamido anchor group. (Cover art: Tomáš Belloň / IOCB Prague)

• Article: Grüner, B.; Kugler, M.; El Anwar, S.; Holub, J.; Nekvinda, J.; Bavol, D.; Růžičková, Z.; Pospíšilová, K.; Fábry, M.; Král, V.; Brynda, J.; Řezáčová, P. Front Cover: Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX (3/2021). ChemPlusChem 2021, 86, 347–347. https://doi.org/10.1002/cplu.202000723
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Cover art: Tomáš Belloň / IOCB Prague

• Article: Weinstain, R.; Slanina, T.; Kand, D.; Klán, P. Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials. Chem. Rev. 2020, 120, 13135–13272. https://doi.org/10.1021/acs.chemrev.0c00663 
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