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Institute of Organic Chemistry
and Biochemistry of the CAS

Take the step towards a career in organic chemistry and biochemistry...


All publications
Preparation of a Key Tetraene Precursor for the Synthesis of Long Acenes
Preparation of a Key Tetraene Precursor for the Synthesis of Long Acenes
G. Levet
N. K. Hung
M. Šámal J. Rybáček
I. Císařová
A. Jančařík
A. Gourdon
European Journal of Organic Chemistry 2020 : Early View (2020).
The tetraene 7,7‐dimethoxy‐2,3,5,6‐tetramethylenebicyclo[2.2.1]heptane is a key compound for the preparation of a large variety of acenes protected by a carbonyl bridge. We report herein a medium scale preparation in seven steps of this valuable starting material. Diels–Alder addition between 6,6‐dimethtyl fulvene and maleic anhydride, followed by carboxylation, ozonolysis of the double bond, reduction of the four ester groups, then chlorination of the alcohol groups and dehydrochlorination give the target compound in 17 % overall yield.
Synergistic effect of leptin and lipidized PrRP on metabolic pathways in ob/ob mice
Journal of Molecular Endocrinology 64 (2): 77-90 (2020).
Pressure dependence of vibrational optical activity of model biomolecules. A computational study
Chirality 2020 : Early View (2020).
T-type channels in neuropathic pain - Villain or victim?
Channels 14 (1): 98-100 (2020).
Tandem Anionic oxy‐Cope Rearrangement/Oxygenation Reactions as a Versatile Method for Approaching Diverse Scaffolds
Angewandte Chemie International Edition 2020 : Early View (2020).

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