Institute of Organic Chemistry
and Biochemistry of the CAS

Take the step towards a career in organic chemistry and biochemistry...


All publications
Influence of Lipid Membranes on α-Synuclein Aggregation
Influence of Lipid Membranes on α-Synuclein Aggregation
ACS Chemical Neuroscience 12 (5): 825–830 (2021)
α-Synuclein is a neuronal protein involved in synaptic vesicle trafficking. During the course of Parkinson’s disease, it aggregates, forming amyloid fibrils that accumulate in the midbrain. This pathological fibrillization process is strongly modulated by physiological interactions of α-synuclein with lipid membranes. However, the detailed mechanism of this effect remains unclear. In this work, we used environment-sensitive fluorescent dyes to study the influence of model lipid membranes on the kinetics of α-synuclein fibrillization. We observed that formation of the fibrils from α-synuclein monomers is strongly delayed even by small amounts of lipids. Furthermore, we found that membrane-bound α-synuclein monomers are not involved in fibril elongation. Hence, presence of lipids slows down fibril growth proportionally to the fraction of membrane-bound protein.
Secondary Structure Libraries for Artificial Evolution Experiments
Molecules 26 (6): 1671 (2021)
Natural and magnetic circular dichroism spectra of nucleosides: effect of the dynamics and environment
RSC Advances 11 (14): 8411-8419 (2021)
Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX
ChemPlusChem 86 (3): 352-363 (2021)

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