Your web browser is out of date. Update your browser for more security, speed and the best experience on this site

Institute of Organic Chemistry
and Biochemistry of the CAS

Take the step towards a career in organic chemistry and biochemistry...


All publications
Structural analysis of the putative SARS-CoV-2 primase complex
Structural analysis of the putative SARS-CoV-2 primase complex
Journal of Structural Biology 211 (2): Early View (2020).
We report the crystal structure of the SARS-CoV-2 putative primase composed of the nsp7 and nsp8 proteins. We observed a dimer of dimers (2:2 nsp7-nsp8) in the crystallographic asymmetric unit. The structure revealed a fold with a helical core of the heterotetramer formed by both nsp7 and nsp8 that is flanked with two symmetry-related nsp8 β-sheet subdomains. It was also revealed that two hydrophobic interfaces one of approx. 1340 Å2 connects the nsp7 to nsp8 and a second one of approx. 950 Å2 connects the dimers and form the observed heterotetramer. Interestingly, analysis of the surface electrostatic potential revealed a putative RNA binding site that is formed only within the heterotetramer.
Mapping of CaM, S100A1 and PIP2-Binding Epitopes in the Intracellular N- and C-Termini of TRPM4
International Journal of Molecular Sciences 21 (12): 4323 (2020).
Acid‐Stable Ester Linkers for the Solid‐Phase Synthesis of Immobilized Peptides
ChemPlusChem 85 (6): 1297-1306 (2020).
SQM/COSMO Scoring Function: Reliable Quantum‐Mechanical Tool for Sampling and Ranking in Structure‐Based Drug Design
ChemPlusChem 2020 : Early View (2020).

Didn’t find what you expected?