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Design Rules for the Nano-Bio Interface of Nanodiamonds: Implications for siRNA Vectorization
Design Rules for the Nano-Bio Interface of Nanodiamonds: Implications for siRNA Vectorization
Advanced Functional Materials 2024: Early View
The enormous therapeutic potential of selective ribonucleic acid (RNA) interference has recently been manifested by the approval of several small interfering RNA (siRNA)-based drugs. However, the efficacy of siRNA delivery is still limited, and an extensive search for alternative and highly effective delivery approaches is ongoing. With this aim, three generations of non-viral vectors based on modified nanodiamonds (NDs) have been gradually developed in the past decade. They show great promise due to the negligible toxicity of the ND core. Here, a robust methodological approach is presented to enable the evaluation of new vector nanomaterials. Using a new type of third-generation ND vector coated with a copolymer with tunable charge density, variables such as colloidal stability, surface electrostatic properties, the molecular composition of the copolymer, and the mode of complexation with siRNA are optimized. Using an innovative data processing strategy, the results are related to…
Polymer-based antibody mimetics (iBodies) target human PD-L1 and function as a potent immune checkpoint blocker
Journal of Biological Chemistry 300 (6): 107325 (2024)
NMR-Challenge.com: Exploring the Most Common Mistakes in NMR Assignments
Journal of Chemical Education 2024: Early View

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