Ústav organické chemie a biochemie

Naši vědci v médiích – výběr z článků, rozhovorů, reportáží
Lipid Nanoparticles for Broad-Spectrum Nucleic Acid Delivery
Lipid Nanoparticles for Broad-Spectrum Nucleic Acid Delivery
Advanced Functional Materials 2021: Early View
Lipid nanoparticles (LNPs) are the most advanced nonviral modality for nucleic acid (NA) delivery, and have recently gained enormous attention in the fields of RNA therapeutics and vaccine development. Here, ionizable adamantane-based lipidoids named XMaNs, which circumvent the usual need for laborious optimization of LNP components for highly diverse types of NAs, are described. The non-toxic XMaN6 lipidoid is highly versatile in entrapment and delivery of siRNA, mRNA, plasmid DNA, and a cyclic dinucleotide. XMaN6-based LNPs efficiently deliver: 1) siRNA into human primary hepatocytes and cell lines that are hard-to-transfect; 2) mRNA into mouse liver; 3) plasmid DNA; 4) 2′,3′-cGAMP into cells and activated the cGAS-STING pathway three orders of magnitude more efficiently than 2′,3′-cGAMP alone. To our knowledge, such universality in delivering different NA types has not been previously described and can accelerate translation of LNPs into the clinic.
Palmitoylation of Prolactin-Releasing Peptide Increased Affinity for and Activation of the GPR10, NPFF-R2 and NPFF-R1 Receptors: In Vitro Study
International Journal of Molecular Sciences 22 (16): 8904 (2021)
The History of Anti-Trypanosome Vaccine Development Shows That Highly Immunogenic and Exposed Pathogen-Derived Antigens Are Not Necessarily Good Target Candidates: Enolase and ISG75 as Examples
Pathogens 10 (8): 1050 (2021)
Enolate-Based Regioselective Anti-Beckmann C–C Bond Cleavage of Ketones
Journal of Organic Chemistry 86 (17): 11608–11632 (2021)
Nonhydrolysable Analogues of (p)ppGpp and (p)ppApp Alarmone Nucleotides as Novel Molecular Tools
ACS Chemical Biology 2021: Early View

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