Profile

Education

2001-2004
Ph.D., Organic Chemistry, Charles University’s Faculty of Science, Prague, Czech Republic
Thesis: Synthesis of Neurosteroids: Modulators of NMDA Receptor

1999-2004
M.Sc., Organic Chemistry, Charles University’s Faculty of Science, Prague, Czech Republic
Diploma work: Synthesis and stability of derivatives of 7-hydroxyepiandrosterone

Appointments

2022-present
Junior Research Group Leader - Neurosteroids, Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague

2012-2022
Targeted Research Group Leaders - Steroidal Inhibitors, Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague

July 2011-December 2011 (6 months)
PostDoctoral Fellow, Department of Medicinal Steroids, Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague

2009-2011 (2 years)
PostDoctoral Research Associate, Washington University in St. Louis School of Medicine, St. Louis, MO, USA
Mentor: Prof. Douglas. F. Covey
Research Focus: Synthesis of neurosteroids and their effects on GABAA receptor function

Research interests

Organic synthesis, medicinal chemistry, steroids, neurosteroids

Selected papers

Latest publications

Cholesterol metabolites modulate ionotropic P2X4 and P2X7 receptor current in microglia cells
Neuropharmacology 266: 110294 (2025)
Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model
International Journal of Molecular Sciences 25 (9): 4637 (2024)
A zuranolone nanocrystal formulation enables solubility-independent in vivo study of pentylenetetrazol-induced seizures in a rat model
RSC Pharmaceutics 1 (1): 37-46 (2024)
C-3 Steroidal Hemiesters as Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 10
ACS Omega 9 (10): 12116–12124 (2024)