Profile

Education

2001-2004
Ph.D., Organic Chemistry, Charles University’s Faculty of Science, Prague, Czech Republic
Thesis: Synthesis of Neurosteroids: Modulators of NMDA Receptor

1999-2004
M.Sc., Organic Chemistry, Charles University’s Faculty of Science, Prague, Czech Republic
Diploma work: Synthesis and stability of derivatives of 7-hydroxyepiandrosterone

Appointments

2022-present
Junior Research Group Leader - Neurosteroids, Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague

2012-2022
Targeted Research Group Leaders - Steroidal Inhibitors, Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague

July 2011-December 2011 (6 months)
PostDoctoral Fellow, Department of Medicinal Steroids, Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague

2009-2011 (2 years)
PostDoctoral Research Associate, Washington University in St. Louis School of Medicine, St. Louis, MO, USA
Mentor: Prof. Douglas. F. Covey
Research Focus: Synthesis of neurosteroids and their effects on GABAA receptor function

Research interests

Organic synthesis, medicinal chemistry, steroids, neurosteroids

Selected papers

Latest publications

FAHFAs are detected in postprandial chylomicron and VLDL fractions and can be released from TG estolides by LPL in vitro
Journal of Lipid Research 67 (6): 101059 (2026)
Steroidal hormones and neurosteroids - novel therapeutic strategies in bacterial infections: Design, synthesis, and biological evaluation
European Journal of Medicinal Chemistry 308: 118716 (2026)
Fluorescence-based assay for rapid screening of GABAA receptor modulating steroid antagonists (GAMSA)
Analytical Biochemistry 711: 116048 (2026)
Pregnanolone-Based Prodrugs as a Strategy for Neuroprotective Drug-Like Compounds: Pregnanolone Pyroglutamate and Its Age‑dependent Anticonvulsant Effects in the 6-hz Seizure Model in Immature Rats
Drug Design, Development and Therapy 20: 566239 (2026)