European Journal of Organic Chemistry2018 (37): 5164-5178
A versatile asymmetric synthesis of five C2 symmetric enantio‐ and diastereopure bioxa[5]‐ and bioxa[6]helicene 2,2′‐bipyridines was developed. It relied either on a double intramolecular [2+2+2] cycloisomerization of dicyanotetrayne (forming simultaneously the 2,2′‐bipyridine unit and biazaoxahelicene backbone) or one‐pot/sequential intramolecular [2+2+2] cycloisomerization of triyne accompanied by an intermolecular haloazaoxahelicene reductive homocoupling. We reached an effective central‐to‐helical‐to‐axial chirality transfer that was controlled by the 1,3‐allylic‐type strain and sterically constricted atropoisomerization of the embedded 2,2′‐bipyridine unit. The chiroptical properties of the bioxahelicene 2,2′‐bipyridines were studied along with their fluorescence properties.
Nonaqueous capillary electrophoresis and quantum chemical calculations applied to investigation of acid–base and electromigration properties of azahelicenes
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