Michal Česnek

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Latest publications

Yohimbine derivatives containing carboxylic acid and ester bioisosteres as potent ADRA2A antagonists

A. Chayka M. Česnek E. Kužmová J. Kozák J. Chalupský A. Dvořáková Z. Osifová M. Dračínský H. Mertlíková-Kaiserová Z. Janeba

European Journal of Medicinal Chemistry 2026: Early View

C1′-Branched Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium Falciparum 6-Oxopurine Phosphoribosyltransferase

J. Frydrych D. T. Keough H. Xia L. Poštová Slavětínská M. Dračínský M. Česnek J. Travis M. Chavchich M. Edstein D. Hocková L. W. Guddat Z. Janeba

ChemMedChem 20 (19): e202500575 (2025)

Structure-Based Drug Design of ADRA2A Antagonists Derived from Yohimbine

A. Chayka M. Česnek E. Kužmová J. Kozák E. Tloušťová A. Dvořáková T. Strmeň B. Brož Z. Osifová M. Dračínský H. Mertlíková-Kaiserová Z. Janeba

Journal of Medicinal Chemistry 67 (12): 10135–10151 (2024)

Discovery of a potent and selective human AC2 inhibitor based on 7-deazapurine analogues of adefovir

P. Kraina M. Česnek E. Tloušťová H. Mertlíková-Kaiserová C. J. Fulton E. K. Davidson B. P. Smith V. J. Watts Z. Janeba

Bioorganic & Medicinal Chemistry 95: 117508 (2023)