Evžen Bouřa

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Latest publications

Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors

J. Šilhán P. Fajtová J. Bartošová B. M. Hurysz J. Almaliti Y. Miyamoto L. Eckmann W. H. Gerwick A. O’Donoghue E. Bouřa

Nature Communications 15: 8621 (2024)

Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5′-carboxamides

H. Kocek D. Chalupská A. Dvořáková M. Zgarbová M. Šála K. Chalupský P. Krafčíková T. Otava M. Drexler E. Procházková B. Klepetářová M. Štefek J. Kozic H. Mertlíková-Kaiserová E. Bouřa J. Weber R. Nencka

RSC Medicinal Chemistry 2024: Early View

Structural and functional insights in flavivirus NS5 proteins gained by the structure of Ntaya virus polymerase and methyltransferase

K. Krejčová P. Krafčíková M. Klíma D. Chalupská K. Chalupský E. Žilecká E. Bouřa

Structure 32 (8): 1099-1109.e3 (2024)

Structure of SARS-CoV-2 MTase nsp14 with the inhibitor STM957 reveals inhibition mechanism that is shared with a poxviral MTase VP39

E. Žilecká M. Klíma M. Štefek M. Dejmek R. Nencka E. Bouřa

Journal of Structural Biology: X 10: 100109 (2024)