Martin Klíma

All publications

Latest publications

SPR is a fast and straightforward method to estimate the binding constants of cyclic dinucleotides to their binding partners, such as STING or poxin

H. Sülzen M. Klíma V. Duchoslav E. Bouřa

Biophysical Chemistry 319: 107392 (2025)

Structural and functional insights in flavivirus NS5 proteins gained by the structure of Ntaya virus polymerase and methyltransferase

K. Krejčová P. Krafčíková M. Klíma D. Chalupská K. Chalupský E. Žilecká E. Bouřa

Structure 32 (8): 1099-1109.e3 (2024)

Structure of SARS-CoV-2 MTase nsp14 with the inhibitor STM957 reveals inhibition mechanism that is shared with a poxviral MTase VP39

E. Žilecká M. Klíma M. Štefek M. Dejmek R. Nencka E. Bouřa

Journal of Structural Biology: X 10: 100109 (2024)

Application of established computational techniques to identify potential SARS-CoV-2 Nsp14-MTase inhibitors in low data regimes

A. K. Nigam M. F. D. Hurley F. Li E. Konkoľová M. Klíma J. Trylčová R. Pollice S. S. Çinaroǧlu R. Levin-Konigsberg J. Handjaya M. Schapira I. Chau S. Perveen H. Ng H. Ü. Kaniskan Y. Han S. Singh C. Gorgulla A. Kundaje J. Jin V. A. Voelz J. Weber R. Nencka E. Bouřa M. Vedadi A. Aspuru-Guzik

Digital Discovery 3 (7): 1327-1341 (2024)