Martin Klíma

All publications

Latest publications

Structural and functional insights in flavivirus NS5 proteins gained by the structure of Ntaya virus polymerase and methyltransferase

K. Krejčová P. Krafčíková M. Klíma D. Chalupská K. Chalupský E. Žilecká E. Bouřa

Structure 32 (8): 1099-1109.e3 (2024)

Structure of SARS-CoV-2 MTase nsp14 with the inhibitor STM957 reveals inhibition mechanism that is shared with a poxviral MTase VP39

E. Žilecká M. Klíma M. Štefek M. Dejmek R. Nencka E. Bouřa

Journal of Structural Biology: X 10: 100109 (2024)

Application of established computational techniques to identify potential SARS-CoV-2 Nsp14-MTase inhibitors in low data regimes

A. K. Nigam M. F. D. Hurley F. Li E. Konkoľová M. Klíma J. Trylčová R. Pollice S. S. Çinaroǧlu R. Levin-Konigsberg J. Handjaya M. Schapira I. Chau S. Perveen H. Ng H. Ü. Kaniskan Y. Han S. Singh C. Gorgulla A. Kundaje J. Jin V. A. Voelz J. Weber R. Nencka E. Bouřa M. Vedadi A. Aspuru-Guzik

Digital Discovery 3 (7): 1327-1341 (2024)

Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function

M. Klíma M. Dejmek V. Duchoslav A. Eisenreichová M. Šála K. Chalupský D. Chalupská B. Novotná G. Birkuš R. Nencka E. Bouřa

Structure 32 (4): 433–439.e4 (2024)