Profile

Education
2004-2008
Ph.D. in Physical chemistry, supervision of Prof. Hobza, Faculty of Science, Charles University in Prague.
1999-2004
M.Sc. in Physical chemistry, Faculty of Science, Charles University in Prague.
Appointments
since 2014
Scientist in Prof. Hobza group, Institute of Organic Chemistry
and Biochemistry of the CAS, Prague.
2010-2014
Postdoctoral fellow in Prof. Hobza group, Institute of Organic Chemistry
and Biochemistry of the CAS, Prague.
2008,2010
Postdoctoral fellow in Prof. Holý group, , Institute of Organic Chemistry
and Biochemistry of the CAS, Prague.
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Latest publications

The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors
ACS Infectious Diseases 2021: Early View
Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors
ACS Infectious Diseases 7 (5): 1077–1088 (2021)
Structural and Thermodynamic Analysis of the Resistance Development to Pimodivir (VX-787), the Clinical Inhibitor of Cap Binding to PB2 Subunit of Influenza A Polymerase
Molecules 26 (4): 1007 (2021)
Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity
ACS Infectious Diseases 7 (1): 189-201 (2021)