Profile

Education
2004-2008
Ph.D. in Physical chemistry, supervision of Prof. Hobza, Faculty of Science, Charles University in Prague.
1999-2004
M.Sc. in Physical chemistry, Faculty of Science, Charles University in Prague.
Appointments
since 2014
Scientist in Prof. Hobza group, Institute of Organic Chemistry
and Biochemistry of the CAS, Prague.
2010-2014
Postdoctoral fellow in Prof. Hobza group, Institute of Organic Chemistry
and Biochemistry of the CAS, Prague.
2008,2010
Postdoctoral fellow in Prof. Holý group, , Institute of Organic Chemistry
and Biochemistry of the CAS, Prague.
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Latest publications

Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes
Journal of Enzyme Inhibition and Medicinal Chemistry 37 (1): 515-526 (2022)
Access to cationic polyhedral carboranes via dynamic cage surgery with N-heterocyclic carbenes
Nature Communications 12: 4971 (2021)
The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors
ACS Infectious Diseases 7 (8): 2214–2220 (2021)
Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors
ACS Infectious Diseases 7 (5): 1077–1088 (2021)