Petra Spiwoková

petra.spiwokova@uochb.cas.cz

+420 220 183 470

Ph.D. student

Michael Mareš Group

Cathepsin Proteases in Pathology

All publications

Latest publications

Fat or flat? The impact of dipole moment vectors on non-covalent interactions between aromatic tags and macromolecules

J. Holub A. Jílková C. Lemke L. Cianni P. Spiwoková M. Horn C. Breuer A. Leontovyč J. Brynda H. Mertlíková-Kaiserová M. Chanová F. dos Reis Rocho C. A. Montanari N. El-Sakkary C. R. Caffrey M. Gütschow D. Hnyk M. Mareš J. Fanfrlík

Inorganic Chemistry Frontiers 13 (2): 364–376 (2026)

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Redirecting the Peptide Cleavage Causes Protease Inactivation

C. Breuer J. Küppers A. Schulz-Fincke A. Heilos C. Lemke P. Spiwoková J. Schmitz L. Cremer M. Frigolé-Vivas M. Lülsdorff M. D. Mertens F. Wichterle M. Apeltauer M. Horn E. Gilberg N. Furtmann J. Bajorath U. Bartz B. Engels M. Mareš M. Gütschow

Angewandte Chemie International Edition 64 (31): e202506832 (2025)

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Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis

P. Spiwoková M. Horn J. Fanfrlík A. Jílková P. Fajtová A. Leontovyč A. Houštecká L. Bieliková J. Brynda M. Chanová H. Mertlíková-Kaiserová E. J. E. Caro-Diaz J. Almaliti N. El-Sakkary W. H. Gerwick C. R. Caffrey M. Mareš

ACS Infectious Diseases 10 (6): 1935–1948 (2024)

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Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes

J. Benýšek M. Buša P. Rubešová J. Fanfrlík M. Lepšík J. Brynda Z. Matoušková U. Bartz M. Horn M. Gütschow M. Mareš

Journal of Enzyme Inhibition and Medicinal Chemistry 37 (1): 515–526 (2022)

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Petra Spiwoková

Latest publications