Jacqueline K. Barton

20 September 2010
IOCB Prague
Prof. Jacqueline K. Barton (Caltech, Pasadena, CA, USA)
DNA-mediated Signaling


Many experiments have now shown that double helical DNA can serve as a conduit for efficient charge transport over long distances. In particular, oxidative damage to DNA can be promoted from a distance as a DNA-mediated redox process. This chemistry is exquisitely sensitive to perturbations in the DNA base stack, such as arise with base mismatches, lesions, and protein binding. As a result, DNA charge transport chemistry can be harnessed for the design of sensitive diagnostics. 

Importantly, this chemistry may also be used advantageously within the cell for long range signaling. Studies are described where DNA charge transport is utilized in signaling DNA-bound proteins, both to regulate transcription and to activate repair of base lesions under conditions of oxidative stress. DNA charge transport chemistry provides an opportunity to carry out redox chemistry at a distance.
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