Prof. Lanny S. Liebeskind (Emory University, Atlanta, GA, USA)
Seeking Novel Reactivity and High Selectivity in Modern Organic Synthesis: Studies of the pH-Neutral, Cu-Catalyzed Formation of Carbon-Carbon and Carbon-Heteroatom Bonds and their Application to Biomedically Relevant Synthesis
Abstract
Achieving high chemoselectivity in functionally complex systems under mild reaction conditions is a significant 21st century challenge for synthetic scientists. In contrast to biological processes, where exquisite selectivity is achieved in vivo in functionally very complex systems through the fine-tuning of protein structure to function, achieving high chemoselectivity on functionally complex molecules in non-enzymatic systems in vitro requires alternative strategies of control. This lecture will describe new control strategies that have led to the development of novel synthetic methods for pH-neutral carbon-carbon and carbon-heteroatom bond formation from nominally unreactive bond types.
