Mini-symposium on new insights about how biological systems can be controlled with light. This traceless reagent enables a vast scope of possibilities to elucidate the yet undiscovered facets of nature. Photoactivatable compounds such as one- and two-photon cages, molecular switches, and activatable fluorophores and sensors represent an important tool for studying and control of biologically relevant processes, such as transcription, translation, protein and DNA folding and biological signalling.
Program
Morning session
8:50 – 9:00
Invitation and opening remarks (Tomáš Slanina & Zdeněk Hostomský)
9:00 – 9:45
Plenary talk – Alexander Heckel: Shedding Light on Nucleic Acids
Research Topic 1: Cages and Switches
9:45 – 10:05
Nikolai Grebenovsky: Amphidynamic Materials as Molecular Machines
10:05 – 10:25
Volker Hermanns: Extending the Photochemical Toolbox
10:25 – 10:45
Janik Kaufmann: Development of BODIPY-Based Light-Inducible Antisense Oligonucleotides for RNA Processing in Plants
Research Topic 2: RNA Control
11:05 – 11:25
Patricia Müller: Development of Light-Inducible AntimiRs as Therapeutic Agents
11:25 – 11:45
Robin Klimek: Regulation of Non-Coding RNA in Neurons
11:45 – 12:05
Anja Blümler: Chemo-Enzymatic Synthesis of Modified RNA
Afternoon session
Research Topic 3: Bioorganic Chemistry of Nucleic Acids
13:30 – 14:15
Plenary talk – Michal Hocek: Modified nucleic acids for diagnostics and chemical biology
14:15 – 14:35
Zuzana Vaníková: Switching of enzymatic cleavage of DNA and transcription through photocaging, deprotection and phosphorylation reactions on DNA
Research Topic 4: 2-Photon Activation
14:35 – 14:55
Yvonne Becker: New Two-Photon Caging Groups and Excitation-Specific Photochemistry
14:55 – 15:15
Rebekka Weber: Enhanced Two-Photon Uncaging via Intramolecular FRET
15:30 – 15:50
Tomáš Slanina: Catch-And-Release: More then bioconjugations
15:50 – 16:35
Plenary talk – Milan Vrábel: Bioorthogonal chemistry of heterodienes: Application in bioimaging and beyond
16:35 – 16:40
Closing remarks (Tomáš Slanina)