Albert Padwa

13 May 2008
IOCB Prague
Prof. Albert Padwa (Emory University, Atlanta, GA, USA)
Cascade Reactions for Alkaloid Synthesis


Sequential transformations enable the facile synthesis of complex natural products from simple building blocks in a single preparative step. Their value is amplified if they also create multiple stereogenic centers. Our research program at Emory has focused on using new cascade reactions of push-pull dipoles and amidofurans for alkaloid synthesis. Our interest in using these domino sequences originated from some earlier work centered on the Rh(II)-catalyzed cyclization/cycloaddition cascade of α-diazoimides containing tethered π-bonds. Making use of these cascade reactions, we have been able to rapidly assemble several alkaloidal systems in excellent yield.
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