Alois Fürstner

12 June 2008
IOCB Prague
Prof. Alois Fürstner (Max-Planck-Institut für Kohlenforschung, Mülheim, Germany)
Catalysis for Total Synthesis


This lecture will provide an up-date on our ongoing programs concerning the total synthesis and evaluation of complex natural products of biological significance. Targets of current interest include the latrunculin family of actin binding macrolides [1], the highly cytotoxic polyene iejimalide [2], various members of the amphidinolide series [3-5], complex glycolipids such as ipomoeassin [6], and the telomerase inhibitors dictyodendrin A-E [7]. All syntheses are largely catalysis-based, featuring the scope of methodology under scrutiny in this laboratory (ring closing alkene- and alkyne metathesis, iron catalyzed coupling reactions, titanium-induced heterocycle syntheses).  


  1. A. Fürstner, D. Kirk, M. D. B. Fenster, C. Aissa, D. De Souza, O. Müller Proc. Natl. Acad. Sci. USA 2005,
    102, 8103. 
  2. A. Fürstner, C. Nevado, M. Waser, M. Tremblay, C. Chevrier, F. Teply, C. Aïssa, E. Moulin, O. Müller J. Am. Chem. Soc. 2007, 129, 9150.  
  3. A. Fürstner, E. Kattnig, O. Lepage J. Am. Chem. Soc. 2006, 128, 9194.
  4. A. Fürstner, O. Larionov, S. Flügge Angew. Chem. Int. Ed. 2007, 46, 5545.
  5. A. Fürstner, L. C. Bouchez, J.-A. Funel, V. Liepins, F.-H. Porée, R. Gilmour, F. Beaufils, D. Laurich, M. Tamiya Angew. Chem. Int. Ed. 2007, 46, 9265.
  6. A. Fürstner, T. Nagano J. Am. Chem. Soc. 2007, 129, 1906.
  7. A. Fürstner, M. M. Domostoj, B. Scheiper J. Am. Chem. Soc. 2006, 128, 8087.
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