15 April 2019
Prof. Venki Ramakrishnan (MRC Laboratory of Molecular Biology, Cambridge, UK)
Termination of Translation in Bacteria and Eukaryotes
Date and time
15 April 2019, 10 p.m.
IOCB Prague, Lecture Hall (Building A, 2nd floor, A2.01)
Termination of translation in all domains of life is triggered by the entry of a stop codon in the A site of the ribosome. These three codons are recognized by a protein release factor. However, release factors in bacteria and eukaryotes appear to have no structural or sequence similarity. In this talk, I will describe structural work that sheds the basis of release factor function in the two domains of life and show that despite their dissimilarity, they share certain common features.