Speaker
Prof. Tatyana Polenova (University of Delaware, Newark, DE, USA)
Topic
Pushing the boundaries of magnetic resonance: Opportunities for chemistry, molecular biophysics, and structural biology
Series
Date and time
3 March 2026, 10 a.m.
Place
IOCB Prague, Lecture Hall
Abstract
I will present our recent work on developing next-generation magnetic resonance methods for atomic-level characterization of large biological assemblies and proteins in their natural cellular environments. I will demonstrate the power of integrating magic angle spinning (MAS) NMR with medium-resolution cryo-EM and data-driven MD simulations to gain comprehensive insights into the structure and dynamics of HIV-1 protein assemblies and connect these to their function. I will introduce 19F dynamic nuclear polarization (DNP)-enhanced MAS NMR spectroscopy in protein assemblies and in proteins within mammalian cells.