5 June 2019
Dr. Jakub Švenda (Masaryk University & International Clinical Research Center, St. Anne’s Hospital, Brno, Czech Republic)
Toward Fully Synthetic Analogs of Bioactive Natural Products
Date and time
5 June 2019, 3 p.m.
IOCB Prague, Lecture Hall (Building A, 2nd floor, A2.01)
Natural products often embody desirable properties of bioactive molecules and have a long history in basic research and human medicine. Few drugs, however, are themselves natural products and the semisynthetic derivatives predominate. Fully synthetic approaches have the exciting potential to deliver novel analogs inaccessible by semisynthesis (or other means) but are confronted with the intrinsic complexity of natural products. In this lecture, I will describe the chemistry effort ongoing in our laboratory that attempts to respond to these challenges and explore the newly created opportunities.