IOCB Most Significant Publications 2018

The most significant publications in CHEM, BIO & PHYS clusters are selected annually by an external international panel of reviewers and the IOCB director.

The awarded publications are listed in their respective clusters alphabetically by title.

• Procházková, E.; Čechová, L.; Kind, J.; Janeba, Z.; Thiele, C. M.; Dračínský, M. Photoswitchable Intramolecular Hydrogen Bonds in 5-Phenylazopyrimidines Revealed By In Situ Irradiation NMR Spectroscopy. Chem. Eur. J. 2018, 24, 492–498. http://dx.doi.org/10.1002/chem.201705146
• Motornov, V.; Markos, A.; Beier, P. A rhodium-catalyzed transannulation of N-(per)fluoroalkyl-1,2,3-triazoles under microwave conditions – a general route to N-(per)fluoroalkyl-substituted five-membered heterocycles. ChemComm 2018, 54, 3258–3261. http://dx.doi.org/10.1039/c8cc01446a
• Tokarenko, A.; Lišková, B.; Smoleń, S.; Táborská, N.; Tichý, M.; Gurská, S.; Perlíková, P.; Frydrych, I.; Tloušt’ová, E.; Znojek, P.; Mertlíková-Kaiserová, H.; Poštová Slavětínská, L.; Pohl, R.; Klepetářová, B.; Khalid, N.-U.-A.; Wenren, Y.; Laposa, R. R.; Džubák, P.; Hajdúch, M.; Hocek, M. Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-Fused 7-Deazapurine Ribonucleosides. J. Med. Chem. 2018, 61, 9347–9359. http://dx.doi.org/10.1021/acs.jmedchem.8b01258

• Sharma, S.; Čermáková, K.; De Rijck, J.; Demeulemeester, J.; Fábry, M.; El Ashkar, S.; Van Belle, S.; Lepšík, M.; Tesina, P.; Duchoslav, V.; Novák, P.; Hubálek, M.; Srb, P.; Christ, F.; Řezáčová, P.; Hodges, H. C.; Debyser, Z.; Veverka, V. Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation. PNAS 2018, 115, E7053–E7062. http://dx.doi.org/10.1073/pnas.1803909115
• Šimon, P.; Knedlík, T.; Blažková, K.; Dvořáková, P.; Březinová, A.; Kostka, L.; Šubr, V.; Konvalinka, J.; Šácha, P. Identification of Protein Targets of Bioactive Small Molecules Using Randomly Photomodified Probes. ACS Chem. Biol. 2018, 13, 3333–3342. http://dx.doi.org/10.1021/acschembio.8b00791
• Hánová, I.; Brynda, J.; Houštecká, R.; Alam, N.; Sojka, D.; Kopáček, P.; Marešová, L.; Vondrášek, J.; Horn, M.; Schueler-Furman, O.; Mareš, M. Novel Structural Mechanism of Allosteric Regulation of Aspartic Peptidases via an Evolutionarily Conserved Exosite. Cell Chem. Biol. 2018, 25, 318–329.e4. http://dx.doi.org/10.1016/j.chembiol.2018.01.001
• Zawada, Z.; Tatar, A.; Mocilac, P.; Buděšínský, M.; Kraus, T. Transport of Nucleoside Triphosphates into Cells by Artificial Molecular Transporters. Angew. Chem. Int. Ed. 2018, 57, 9891–9895. http://dx.doi.org/10.1002/anie.201801306

• Allolio, C.; Magarkar, A.; Jurkiewicz, P.; Baxová, K.; Javanainen, M.; Mason, P. E.; Šachl, R.; Cebecauer, M.; Hof, M.; Horinek, D.; Heinz, V.; Rachel, R.; Ziegler, C. M.; Schröfel, A.; Jungwirth, P. Arginine-rich cell-penetrating peptides induce membrane multilamellarity and subsequently enter via formation of a fusion pore. PNAS 2018, 115, 11923–11928. http://dx.doi.org/10.1073/pnas.1811520115
• Havlik, J.; Petrakova, V.; Kucka, J.; Raabova, H.; Panek, D.; Stepan, V.; Zlamalova Cilova, Z.; Reineck, P.; Stursa, J.; Kucera, J.; Hruby, M.; Cigler, P. Extremely rapid isotropic irradiation of nanoparticles with ions generated in situ by a nuclear reaction. Nat. Commun. 2018, 9, 4467. http://dx.doi.org/10.1038/s41467-018-06789-8
• Stetsovych, O.; Mutombo, P.; Švec, M.; Šámal, M.; Nejedlý, J.; Císařová, I.; Vázquez, H.; Moro-Lagares, M.; Berger, J.; Vacek, J.; Stará, I. G.; Starý, I.; Jelínek, P. Large Converse Piezoelectric Effect Measured on a Single Molecule on a Metallic Surface. J. Am. Chem. Soc. 2018, 140, 940–946. http://dx.doi.org/10.1021/jacs.7b08729
• de la Torre, B.; Švec, M.; Hapala, P.; Redondo, J.; Krejčí, O.; Lo, R.; Manna, D.; Sarmah, A.; Nachtigallová, D.; Tuček, J.; Błoński, P.; Otyepka, M.; Zbořil, R.; Hobza, P.; Jelínek, P. Non-covalent control of spin-state in metal-organic complex by positioning on N-doped graphene. Nat. Commun. 2018, 9, 2831. http://dx.doi.org/10.1038/s41467-018-05163-y
• Vícha, J.; Komorovsky, S.; Repisky, M.; Marek, R.; Straka, M. Relativistic Spin–Orbit Heavy Atom on the Light Atom NMR Chemical Shifts: General Trends Across the Periodic Table Explained. J. Chem. Theory Comput. 2018, 14, 3025–3039. http://dx.doi.org/10.1021/acs.jctc.8b00144