IOCB Most Significant Publications 2024

The most significant publications in CHEM, BIO & PHYS clusters are selected annually by an external international panel of reviewers and the IOCB director.

The awarded publications are listed in their respective clusters alphabetically by title.

• Baris, N.; Dračínský, M.; Tarábek, J.; Filgas, J.; Slavíček, P.; Ludvíková, L.; Boháčová, S.; Slanina, T.; Klepetářová, B.; Beier, P. Photocatalytic Generation of Trifluoromethyl Nitrene for Alkene Aziridination. Angewandte Chemie - International Edition 2024, 63 (2),e202315162. https://doi.org/10.1002/anie.202315162
• Brunderová, M.; Havlíček, V.; Matyašovský, J.; Pohl, R.; Poštová Slavětínská, L.; Krömer, M.; Hocek, M. Expedient production of site specifically nucleobase-labelled or hypermodified RNA with engineered thermophilic DNA polymerases. Nature Communications 2024, 15, 3054. https://doi.org/10.1038/s41467-024-47444-9
• Kretschmer, J.; Chiaffarelli, R.; Vuozzo, M.; Cotton, J.; Blahut, J.; Ráliš, J.; Dračínský, M.; Matějková, S.; Seeling, U.; Schmid, A.; Martins, A.; Polášek, M. A Macrocyclic Hybrid PET/MRI Probe for Quantitative Perfusion Imaging In Vivo. Angewandte Chemie - International Edition 2024, 63 (48), e202409520. https://doi.org/10.1002/anie.202409520

Director's Award

• Heuckeroth, S.; Damiani, T.; Smirnov, A.; Mokshyna, O.; Brungs, C.; Korf, A.; Smith, J.D.; Stincone, P.; Dreolin, N.; Nothias, L.; Hyötyläinen, T.; Orešič, M.; Karst, U.; Dorrestein, P.; Petras, D.; Du, X.; van der Hooft, J.; Schmid, R.; Pluskal, T. Reproducible mass spectrometry data processing and compound annotation in MZmine 3. Nature Protocols 2024, 19, 2597-2641. https://doi.org/10.1038/s41596-024-00996-y

• Bulvas, O.; Knejzlík, Z.; Sýs, J.; Filimoněnko, A.; Čížková, M.; Clarová, K.; Rejman, D.; Kouba, T.; Pichová, I. Deciphering the allosteric regulation of mycobacterial inosine-5'-monophosphate dehydrogenase. Nature Communications 2024, 15, 6673. https://doi.org/10.1038/s41467-024-50933-6
• Hadzima, M.; Faucher, F.; Blažková, K.; Yim, J.; Guerra, M.; Chen, S.; Woods, E.; Park, K.; Šácha, P.; Šubr, V.; Kostka, L.; Etrych, T.; Majer, P.; Konvalinka, J.; Bogyo, M. Polymer-Tethered Quenched Fluorescent Probes for Enhanced Imaging of Tumor-Associated Proteases. ACS Sensors 2024, 9, 3720-3729. https://doi.org/10.1021/acssensors.4c00912
• Potužník, J.F.; Nešuta, O.; Škríba, A.; Voleníková, B.; Mititelu, M.B.; Mancini, F.; Serianni, V.; Fernandez, H.; Spustová, K.; Trylčová, J.; Vopálenský, P.; Cahová, H. Diadenosine Tetraphosphate (Ap4A) Serves as a 5′ RNA Cap in Mammalian Cells. Angewandte Chemie - International Edition 2024, 63 (6), e202314951. https://doi.org/10.1002/anie.202314951
• Šoltysová, M.; Škerlová, J.; Pachl, P.; Škubník, K.; Fábry, M.; Sieglová, I.; Farolfi, M.; Grishkovskaya, I.; Babiak, M.; Nováček, J.; Krásný, L.; Řezáčová, P. Structural characterization of two prototypical repressors of SorC family reveals tetrameric assemblies on DNA and mechanism of function. Nucleic Acids Research 2024, 52 (12), 7305-7320. https://doi.org/10.1093/nar/gkae434

• Pecina, A.; Fanfrlík, J.; Lepšík, M.; Řezáč, J. SQM2.20: Semiempirical quantum-mechanical scoring function yields DFT-quality protein-ligand binding affinity predictions in minutes. Nature Communications 2024, 15, 1127. https://doi.org/10.1038/s41467-024-45431-8
• Manna, D.; Lo, R.; Vacek, J.; Miriyala, V.M.; Bouř, P.; Wu, T.; Osifová, Z.; Nachtigallová, D.; Dračínský, M.; Hobza, P. The Stability of Hydrogen-Bonded Ion-Pair Complex Unexpectedly Increases with Increasing Solvent Polarity. Angewandte Chemie - International Edition 2024, 63 (20), e202403218. https://doi.org/10.1002/anie.202403218
• Nemirovich, T.; Young, B.; Březina, K.; Mason, P.E.; Seidel, R.; Stemer, D.; Winter, B.; Jungwirth, P.; Bradforth, S.; Schewe, H.C. Stability and Reactivity of Aromatic Radical Anions in Solution with Relevance to Birch Reduction. Journal of the American Chemical Society 2024, 146 (12), 8043-8057. https://doi.org/10.1021/jacs.3c11655