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Radim Nencka, Ph.D.

mail radim.nenckainvalid-email-name@invalid-email-domainuochb.cas.cz
telefon +420 220 183 265
Group leader
Radim Nencka Group
Drug Design and Medicinal Chemistry

Profile

Education
1996-2001
M.Sc. in Pharmacy, at Charles University in Prague, Faculty of Pharmacy in Hradec Králové (under supervision of Prof. Manolis Stratakis at University of Crete, Greece and Miroslav Miletín, Ph.D. at Charles University).
2001-2008
Ph.D. in Organic Chemistry at Department of Organic Chemistry, Charles University, Prague; (under supervision of Dr. H. Hřebabecký at Institute of Organic Chemistry and Biochemistry of the CAS).
Appointments
2009-2010
Postdoctoral Fellow at Laboratory of Medicinal Chemistry (Prof. Serge Van Calenbergh), Faculty of Pharmaceutical Sciences, University of Ghent, Ghent, Belgium. (Synthesis of nucleotide analogues as P2Y2 receptor ligands).
2001 (5 months)
Short stay at University of Crete, Heraklion, Greece.
Since 2010
Head of the Junior Research Team, Institute of Organic Chemistry and Biochemistry of the CAS.
All publications

Latest publications

Compounds mimicking the Michaelis-Menten transition state of the phosphatidylinositol 4-kinase
H. Hřebabecký M. Klíma M. Dejmek P. Krupa M. Riopedre Fernández E. Dávidová J. Benýšek H. Martinez-Seara B. Rozycki E. Bouřa R. Nencka
Bioorganic & Medicinal Chemistry 139: 118666 (2026)
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Autophagy revealed as a targetable vulnerability in senescent cells by cell painting phenotypic profiling: a mechanistic study of MCOPPB and related compounds
M. Lacey L. Béresová A. Srovnalová P. Polishchuk M. Šála Z. Skrott M. Hajdúch P. Džubák J. Bartek A. Šišková M. Loffelmann R. Nencka M. Mistrík
GeroScience 2026: Early View
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Structural mechanism and inhibitor discovery for DhhP, a Borrelia burgdorferi cyclic di-AMP phosphodiesterase with an Fe/Mn bimetallic center
M. Klíma M. Dejmek A. Palusová D. Chalupská P. Pachl A. Hušková J. Hraníček K. Chalupský M. Moos R. Nencka J. Perner E. Bouřa
Structure 2026: Early View
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