CS

Radim Nencka, Ph.D.

mail radim.nenckainvalid-email-name@invalid-email-domainuochb.cas.cz
phone +420 220 183 265
Group leader
Radim Nencka Group
Drug Design and Medicinal Chemistry

Profile

Education
1996-2001
M.Sc. in Pharmacy, at Charles University in Prague, Faculty of Pharmacy in Hradec Králové (under supervision of Prof. Manolis Stratakis at University of Crete, Greece and Miroslav Miletín, Ph.D. at Charles University).
2001-2008
Ph.D. in Organic Chemistry at Department of Organic Chemistry, Charles University, Prague; (under supervision of Dr. H. Hřebabecký at Institute of Organic Chemistry and Biochemistry of the CAS).
Appointments
2009-2010
Postdoctoral Fellow at Laboratory of Medicinal Chemistry (Prof. Serge Van Calenbergh), Faculty of Pharmaceutical Sciences, University of Ghent, Ghent, Belgium. (Synthesis of nucleotide analogues as P2Y2 receptor ligands).
2001 (5 months)
Short stay at University of Crete, Heraklion, Greece.
Since 2010
Head of the Junior Research Team, Institute of Organic Chemistry and Biochemistry of the CAS.
All publications

Latest publications

Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases
M. Misehe M. Matoušová K. Hercík K. Škach D. Chalupská M. Dejmek M. Šála M. Hájek E. Bouřa H. Mertlíková-Kaiserová R. Nencka
European Journal of Medicinal Chemistry 260: 115717 (2023)
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Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy
M. Dejmek A. Brázdová T. Otava M. Pimková Polidarová M. Klíma M. Smola Z. Vavřina M. Buděšínský M. Dračínský R. Liboska E. Bouřa G. Birkuš R. Nencka
European Journal of Medicinal Chemistry 259: 115685 (2023)
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