Profile

Research Interests

organic synthesis, flow chemistry, chiral separations, HPLC and SFC, electron microscopy

Education

2008

Ph.D. in Organic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology, Prague, under supervision of Dr. Petr Holý at the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague

2006

Erasmus internship at the University of Copenhagen, Denmark, Department of Chemistry, under supervision of Prof. Mogens Brøndsted Nielsen

2003

M.Sc. in Organic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology, Prague, under supervision of Assoc. Prof. Stanislav Böhm

Chronology of Employment

since 2003

Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Ivo Starý Group, Current Position: Research Scientist 

Publications

34 original papers / h-index: 15

Selected papers

Racemic and Optically Pure Heptahelicene-2-carboxylic Acid: Its Synthesis and Self-Assembly into Nanowire-Like Aggregates
Racemic and Optically Pure Heptahelicene-2-carboxylic Acid: Its Synthesis and Self-Assembly into Nanowire-Like Aggregates
European Journal of Organic Chemistry 2011 (5): 853-860
Heptahelicene‐2‐carboxylic acid was effectively synthesised from suitably functionalised naphthalene building blocks. Methoxy‐substituted 1,1′‐ethyne‐1,2‐diylbis(2‐but‐3‐yn‐1‐ylnaphthalene) was cyclised in the presence of CpCo(CO)2/PPh3 to 2‐methoxy‐7,8,11,12‐tetrahydroheptahelicene, which was converted into heptahelicen‐2‐yl trifluoromethanesulfonate. This reactive intermediate underwent Pd(OAc)2/dppp‐catalysed methoxycarbonylation reaction to provide, after hydrolysis, heptahelicene‐2‐carboxylic acid. The racemate was resolved into enantiomers by semipreparative HPLC on a chiral column. The helicity of (+)‐(P)‐heptahelicene‐2‐carboxylic acid was assigned by correlating its CD spectrum to that of the known (+)‐(P)‐heptahelicene. Racemic heptahelicene‐2‐carboxylic acid was deposited on calcite (10‐14) to undergo self‐assembly into nanowire‐like aggregates as demonstrated by noncontact atomic force microscopy (NC‐AFM).
Tetrathiafulvalene-functionalized triptycenes: synthetic protocols and elucidation of intramolecular Coulomb repulsions in the oxidized species
Tetrahedron 63 (36): 8840-8854 (2007)
Synthesis of Extended Bifunctional Triptycenes
Synthesis 2008 (22): 3615-3618

Latest publications

Thermal evaporation as sample preparation for silver–assisted laser desorption/ionization mass spectrometry imaging of cholesterol in amyloid tissues
Analyst 2024: Early View
β-Disubstituted Pentacene Derivatives: Thin Film Structural Properties and Four-Probe Field Effect Mobility
ChemPlusChem 2023: Early View
Helical Bilayer Nanographenes: Impact of the Helicene Length on the Structural, Electrochemical, Photophysical, and Chiroptical Properties
Journal of the American Chemical Society 145 (21): 11599–11610 (2023)