Profile

Research Interests

organic synthesis, flow chemistry, chiral separations, HPLC and SFC, electron microscopy

Education

2008

Ph.D. in Organic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology, Prague, under supervision of Dr. Petr Holý at the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague

2006

Erasmus internship at the University of Copenhagen, Denmark, Department of Chemistry, under supervision of Prof. Mogens Brøndsted Nielsen

2003

M.Sc. in Organic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology, Prague, under supervision of Assoc. Prof. Stanislav Böhm

Chronology of Employment

since 2003

Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Ivo Starý Group, Current Position: Research Scientist 

Publications

24 original papers / h-index: 12

Selected papers

Racemic and Optically Pure Heptahelicene-2-carboxylic Acid: Its Synthesis and Self-Assembly into Nanowire-Like Aggregates
Racemic and Optically Pure Heptahelicene-2-carboxylic Acid: Its Synthesis and Self-Assembly into Nanowire-Like Aggregates
European Journal of Organic Chemistry 2011 (5): 853-860
Heptahelicene‐2‐carboxylic acid was effectively synthesised from suitably functionalised naphthalene building blocks. Methoxy‐substituted 1,1′‐ethyne‐1,2‐diylbis(2‐but‐3‐yn‐1‐ylnaphthalene) was cyclised in the presence of CpCo(CO)2/PPh3 to 2‐methoxy‐7,8,11,12‐tetrahydroheptahelicene, which was converted into heptahelicen‐2‐yl trifluoromethanesulfonate. This reactive intermediate underwent Pd(OAc)2/dppp‐catalysed methoxycarbonylation reaction to provide, after hydrolysis, heptahelicene‐2‐carboxylic acid. The racemate was resolved into enantiomers by semipreparative HPLC on a chiral column. The helicity of (+)‐(P)‐heptahelicene‐2‐carboxylic acid was assigned by correlating its CD spectrum to that of the known (+)‐(P)‐heptahelicene. Racemic heptahelicene‐2‐carboxylic acid was deposited on calcite (10‐14) to undergo self‐assembly into nanowire‐like aggregates as demonstrated by noncontact atomic force microscopy (NC‐AFM).
Tetrathiafulvalene-functionalized triptycenes: synthetic protocols and elucidation of intramolecular Coulomb repulsions in the oxidized species
Tetrahedron 63 (36): 8840-8854 (2007)
Synthesis of Extended Bifunctional Triptycenes
Synthesis 2008 (22): 3615-3618

Latest publications

Preparation of a Key Tetraene Precursor for the Synthesis of Long Acenes
European Journal of Organic Chemistry 2020 (11): 1658-1664
Synthesis of Racemic, Diastereopure, and Enantiopure Carba- or Oxa[5]-, [6]-, [7]-, and -[19]helicene (Di)thiol Derivatives
Journal of Organic Chemistry 85 (1): 248-276 (2020)
Chirality-Controlled Self-Assembly of Amphiphilic Dibenzo[6]helicenes into Langmuir-Blodgett Thin Films
Chemistry - A European Journal 25 (49): 11494-11502 (2019)
Antimicrobial peptides prevent bacterial biofilm formation on the surface of polymethylmethacrylate bone cement
Journal of Medical Microbiology 68 (6): 961-972 (2019)