Profil

Oblasti zájmu

organická syntéza, průtočná chemie, chirální separace, HPLC a SFC, elektronová mikroskopie

Vzdělání

2008
Ph.D. v  oboru organické chemie, Fakulta chemické technologie, Vysoká škola chemicko-technologická v Praze, pod vedením Ing. Petra Holého, CSc. na Ústavu organické chemie a biochemie Akademie věd České republiky, Praha
2006
stáž v rámci programu Erasmus na University of Copenhagen, Dánsko, Department of Chemistry, pod vedením prof. Mogens Brøndsted Nielsena
2003
inženýr organické chemie, Fakulta chemické technologie, Vysoká škola chemicko-technologická v Praze, pod vedením Doc. Stanislava Böhma, CSc.

Zaměstnání

od 2003
vědecký pravovník ve skupině RNDr. Iva Starého, CSc., Ústav organické chemie a biochemie Akademie věd České republiky, v.v.i., Praha

Publikace

24 původních článků / h-index: 12

Vybrané publikace

Racemic and Optically Pure Heptahelicene-2-carboxylic Acid: Its Synthesis and Self-Assembly into Nanowire-Like Aggregates
Racemic and Optically Pure Heptahelicene-2-carboxylic Acid: Its Synthesis and Self-Assembly into Nanowire-Like Aggregates
European Journal of Organic Chemistry 2011 (5): 853-860
Heptahelicene‐2‐carboxylic acid was effectively synthesised from suitably functionalised naphthalene building blocks. Methoxy‐substituted 1,1′‐ethyne‐1,2‐diylbis(2‐but‐3‐yn‐1‐ylnaphthalene) was cyclised in the presence of CpCo(CO)2/PPh3 to 2‐methoxy‐7,8,11,12‐tetrahydroheptahelicene, which was converted into heptahelicen‐2‐yl trifluoromethanesulfonate. This reactive intermediate underwent Pd(OAc)2/dppp‐catalysed methoxycarbonylation reaction to provide, after hydrolysis, heptahelicene‐2‐carboxylic acid. The racemate was resolved into enantiomers by semipreparative HPLC on a chiral column. The helicity of (+)‐(P)‐heptahelicene‐2‐carboxylic acid was assigned by correlating its CD spectrum to that of the known (+)‐(P)‐heptahelicene. Racemic heptahelicene‐2‐carboxylic acid was deposited on calcite (10‐14) to undergo self‐assembly into nanowire‐like aggregates as demonstrated by noncontact atomic force microscopy (NC‐AFM).
Tetrathiafulvalene-functionalized triptycenes: synthetic protocols and elucidation of intramolecular Coulomb repulsions in the oxidized species
Tetrahedron 63 (36): 8840-8854 (2007)
Synthesis of Extended Bifunctional Triptycenes
Synthesis 2008 (22): 3615-3618

Nejnovější publikace

Preparation of a Key Tetraene Precursor for the Synthesis of Long Acenes
European Journal of Organic Chemistry 2020 (11): 1658-1664
Synthesis of Racemic, Diastereopure, and Enantiopure Carba- or Oxa[5]-, [6]-, [7]-, and -[19]helicene (Di)thiol Derivatives
Journal of Organic Chemistry 85 (1): 248-276 (2020)
Chirality-Controlled Self-Assembly of Amphiphilic Dibenzo[6]helicenes into Langmuir-Blodgett Thin Films
Chemistry - A European Journal 25 (49): 11494-11502 (2019)
Antimicrobial peptides prevent bacterial biofilm formation on the surface of polymethylmethacrylate bone cement
Journal of Medical Microbiology 68 (6): 961-972 (2019)