Jiří Brynda

jiri.brynda@uochb.cas.cz

+420 220 183 210

Scientist

Pavlína Maloy Řezáčová Group

Structural Biology

All publications

Latest publications

Affinity and Selectivity of Protein–Ligand Recognition: A Minor Chemical Modification Changes Carbonic Anhydrase Binding Profile

A. Zakšauskas V. Paketurytė-Latvė A. Janku̅naitė E. Čapkauskaitė Y. Becart A. Smirnov K. Pospíšilová J. Leitans J. Brynda A. Kazaks L. Baranauskienė E. Manakova S. Gražulis V. Kairys K. Tars P. Řezáčová D. Matulis

Journal of Medicinal Chemistry 68 (16): 17752–17773 (2025)

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Beyond Natural Flavonoids: Exploring Bioisosterism in Design and Synthesis of Influenza Endonuclease Inhibitors

R. Reiberger M. Kráľ K. Radilová T. Kotačka A. Tsalyy P. Majer M. Dračínský J. Brynda J. Konvalinka M. Kožíšek A. Machara

RSC Medicinal Chemistry 16 (7): 3030-3048 (2025)

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On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents

R. Kryštůfek V. Verner P. Šácha M. Hadzima F. Trajhan J. Starková E. Tloušťová A. Dvořáková A. Pecina J. Brynda J. Chalupský M. Hájek M. J. Boucher P. Majer J. Řezáč H. D. Madhani C. S. Craik J. Konvalinka

Journal of Medicinal Chemistry 68 (9): 9623–9637 (2025)

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Using environment-sensitive tetramethylated thiophene-BODIPY fluorophores in DNA probes for studying effector-induced conformational changes of protein–DNA complexes

M. Šoltysová P. Güixens-Gallardo I. Sieglová A. Soldánová V. Krejčiříková M. Fábry J. Brynda P. Khoroshyy M. Hocek P. Řezáčová

RSC Chemical Biology 6 (3): 376–386 (2025)

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Jiří Brynda

Latest publications