CS
Aleš Machara, Ph.D.

Aleš Machara, Ph.D.

mail ales.macharainvalid-email-name@invalid-email-domainuochb.cas.cz
phone +420 220 183 479
Scientist
Pavel Majer Group
Drug Discovery
All publications

Latest publications

Design, synthesis, and activity evaluation of C-8 arylated luteolin derivatives as influenza endonuclease inhibitors
A. Tsalyy M. Kráľ R. Reiberger P. Majer J. Konvalinka M. Kožíšek A. Machara
Bioorganic and Medicinal Chemistry Letters 121: 130178 (2025)
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Beyond Natural Flavonoids: Exploring Bioisosterism in Design and Synthesis of Influenza Endonuclease Inhibitors
R. Reiberger M. Kráľ K. Radilová T. Kotačka A. Tsalyy P. Majer M. Dračínský J. Brynda J. Konvalinka M. Kožíšek A. Machara
RSC Medicinal Chemistry 2025: Early View
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3′-Dehydroxypurpurogallin-4-Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure-Activity Relationship Analysis, and Structural Characterization of Protein Complex
M. Kráľ T. Kotačka R. Reiberger G. Panýrková K. Radilová Z. Osifová M. Flieger J. Konvalinka P. Majer M. Kožíšek A. Machara
ChemMedChem 20 (3): e202400577 (2025)
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The evaluation of DNA-linked inhibitor antibody and AlphaScreen assays for high-throughput screening of compounds targeting the cap-binding domain in influenza a polymerase
K. Čermáková J. Gregor M. Kráľ E. Karlukova V. Navrátil R. Reiberger C. Berenguer Albinana V. Bechynský P. Majer J. Konvalinka A. Machara M. Kožíšek
European Journal of Pharmaceutical Sciences 205: 106990 (2025)
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