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9/2017 – present
Part of a collaborative research project aimed at novel cyclic dinucleotides (CDNs) – their synthesis and and biological activity. Project leader: Dr. Gabriel Birkuš, Gilead Sciences & IOCB research centre.
7/2015 - present
Researcher position at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic in the team of Dr. Radim Nencka.
5/2014 - 4/2015
Postdoctoral research at the Ludwig-Maxmilian Universität, Munich in the group of Prof. Thomas Carell.
• Synthesis and evaluation of DNA-DNA crosslinkers.
• Development of new isobaric labels for mass spectrometry.
• Development of selective peptide labeling methodology.
1/2013 - 4/2014
Postdoctoral research in the Gilead Sciences & IOCB research centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic. Project leaders: Dr. Eric Lansdon and Dr. Petr Jansa (Gilead Sciences, USA).
• Synthesis of modified heterocycles.
9/2007 - 12/2012
Graduate research at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic in the team of prof. Holý (after his retirement in 2011 in the team of Dr. Nencka). Supervisor: Dr. Hubert Hřebabecký.
9/2006 - 9/2007
Undergraduate research at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic in the team of prof. Holý. Supervisor: Dr. Hubert Hřebabecký.
Milan Dejmek
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Latest publications
Structure of SARS-CoV-2 MTase nsp14 with the inhibitor STM957 reveals inhibition mechanism that is shared with a poxviral MTase VP39
Journal of Structural Biology: X 10: 100109 (2024)
Novel analogues of a nonnucleoside SARS-CoV-2 RdRp inhibitor as potential antivirotics
Beilstein Journal of Organic Chemistry 20: 1029–1036 (2024)
Acidity constants and protonation sites of cyclic dinucleotides determined by capillary electrophoresis, quantum chemical calculations, and NMR spectroscopy
Electrophoresis 45 (7–8): 687–705 (2024)
Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function
Structure 32 (4): 433–439.e4 (2024)