Profile

9/2017 – present
Part of a collaborative research project aimed at novel cyclic dinucleotides (CDNs) – their synthesis and and biological activity. Project leader: Dr. Gabriel Birkuš, Gilead Sciences & IOCB research centre.


7/2015 - present

Researcher position at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic in the team of Dr. Radim Nencka.

5/2014 - 4/2015
Postdoctoral research at the Ludwig-Maxmilian Universität, Munich in the group of Prof. Thomas Carell.
•    Synthesis and evaluation of DNA-DNA crosslinkers.
•    Development of new isobaric labels for mass spectrometry.
•    Development of selective peptide labeling methodology.


1/2013 - 4/2014

Postdoctoral research in the Gilead Sciences & IOCB research centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic. Project leaders: Dr. Eric Lansdon and Dr. Petr Jansa (Gilead Sciences, USA).
•    Synthesis of modified heterocycles.

9/2007 - 12/2012

Graduate research at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic in the team of prof. Holý (after his retirement in 2011 in the team of Dr. Nencka). Supervisor: Dr. Hubert Hřebabecký.

9/2006 - 9/2007

Undergraduate research at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic in the team of prof. Holý. Supervisor: Dr. Hubert Hřebabecký.

Selected papers

Latest publications

Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases
European Journal of Medicinal Chemistry 260: 115717 (2023)
Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy
European Journal of Medicinal Chemistry 259: 115685 (2023)