Profile

9/2017 – present
Part of a collaborative research project aimed at novel cyclic dinucleotides (CDNs) – their synthesis and and biological activity. Project leader: Dr. Gabriel Birkuš, Gilead Sciences & IOCB research centre.


7/2015 - present

Researcher position at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic in the team of Dr. Radim Nencka.

5/2014 - 4/2015
Postdoctoral research at the Ludwig-Maxmilian Universität, Munich in the group of Prof. Thomas Carell.
•    Synthesis and evaluation of DNA-DNA crosslinkers.
•    Development of new isobaric labels for mass spectrometry.
•    Development of selective peptide labeling methodology.


1/2013 - 4/2014

Postdoctoral research in the Gilead Sciences & IOCB research centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic. Project leaders: Dr. Eric Lansdon and Dr. Petr Jansa (Gilead Sciences, USA).
•    Synthesis of modified heterocycles.

9/2007 - 12/2012

Graduate research at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic in the team of prof. Holý (after his retirement in 2011 in the team of Dr. Nencka). Supervisor: Dr. Hubert Hřebabecký.

9/2006 - 9/2007

Undergraduate research at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic in the team of prof. Holý. Supervisor: Dr. Hubert Hřebabecký.

Selected papers

Latest publications

Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3′,3′-c-Di(2′F,2′dAMP)
Journal of Medicinal Chemistry 64 (11): 7596–7616 (2021)
Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein
Angewandte Chemie International Edition 60 (18): 10172-10178 (2021)
Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA)
SLAS Discovery 25 (9): 1026-1037 (2020)
Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses
Antiviral Research 182: 104899 (2020)