Profil

Životopis

9/2017 – present
Part of a collaborative research project aimed at novel cyclic dinucleotides (CDNs) – their synthesis and and biological activity. Project leader: Dr. Gabriel Birkuš, Gilead Sciences & IOCB research centre.


7/2015 - present
Researcher position at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic in the team of Dr. Radim Nencka.

5/2014 - 4/2015
Postdoctoral research at the Ludwig-Maxmilian Universität, Munich in the group of Prof. Thomas Carell.
•    Synthesis and evaluation of DNA-DNA crosslinkers.
•    Development of new isobaric labels for mass spectrometry.
•    Development of selective peptide labeling methodology.


1/2013 - 4/2014
Postdoctoral research in the Gilead Sciences & IOCB research centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic. Project leaders: Dr. Eric Lansdon and Dr. Petr Jansa (Gilead Sciences, USA).
•    Synthesis of modified heterocycles.

9/2007 - 12/2012
Graduate research at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic in the team of prof. Holý (after his retirement in 2011 in the team of Dr. Nencka). Supervisor: Dr. Hubert Hřebabecký.

9/2006 - 9/2007
Undergraduate research at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic in the team of prof. Holý. Supervisor: Dr. Hubert Hřebabecký.

Vybrané publikace

Nejnovější publikace

Structural mechanism and inhibitor discovery for DhhP, a Borrelia burgdorferi cyclic di-AMP phosphodiesterase with an Fe/Mn bimetallic center
Structure 2026: Early View
C7-Sulfonamide functionalization of 7-deazaadenosines: sangivamycin analogues with Haspin inhibitory activity
Chemical Communications 62 (8): 2633–2636 (2026)
Mechanistic insights into alcohol-induced DNA crosslink repair by Slx4-Xpf-Ercc1 nuclease complex in the Fanconi anaemia pathway
Communications Biology 8: 1374 (2025)
Structure of SARS-CoV-2 MTase nsp14 with the inhibitor STM957 reveals inhibition mechanism that is shared with a poxviral MTase VP39
Journal of Structural Biology: X 10: 100109 (2024)