Profil

Životopis

9/2017 – present
Part of a collaborative research project aimed at novel cyclic dinucleotides (CDNs) – their synthesis and and biological activity. Project leader: Dr. Gabriel Birkuš, Gilead Sciences & IOCB research centre.


7/2015 - present
Researcher position at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic in the team of Dr. Radim Nencka.

5/2014 - 4/2015
Postdoctoral research at the Ludwig-Maxmilian Universität, Munich in the group of Prof. Thomas Carell.
•    Synthesis and evaluation of DNA-DNA crosslinkers.
•    Development of new isobaric labels for mass spectrometry.
•    Development of selective peptide labeling methodology.


1/2013 - 4/2014
Postdoctoral research in the Gilead Sciences & IOCB research centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic. Project leaders: Dr. Eric Lansdon and Dr. Petr Jansa (Gilead Sciences, USA).
•    Synthesis of modified heterocycles.

9/2007 - 12/2012
Graduate research at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic in the team of prof. Holý (after his retirement in 2011 in the team of Dr. Nencka). Supervisor: Dr. Hubert Hřebabecký.

9/2006 - 9/2007
Undergraduate research at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic in the team of prof. Holý. Supervisor: Dr. Hubert Hřebabecký.

Vybrané publikace

Nejnovější publikace

SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia
Cancer Research 83 (7): 983–996 (2023)
Synthetic Stimulator of Interferon Genes (STING) Agonists Induce a Cytokine-Mediated Anti-Hepatitis B Virus Response in Nonparenchymal Liver Cells
ACS Infectious Diseases 9 (1): 23–32 (2023)
Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists
Journal of Medicinal Chemistry 65 (20): 14082–14103 (2022)
Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold
Bioorganic and Medicinal Chemistry Letters 76: 129010 (2022)