Profile

Research Interests

Organic Synthesis, Single-Molecule Conductance Measurement

Education

2021

Ph.D. in Organic Chemistry at the Faculty of Natural Sciences, Charles University, Prague, under supervision of Dr. Ivo Starý at the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague

2012

M.Sc. in Organic Chemistry at the Faculty of Natural Sciences, Charles University, Prague, under supervision of Dr. Ivo Starý at the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague

2010

Bc. in Organic Chemistry at the Faculty of Natural Sciences, Charles University, Prague, under supervision of Dr. Ivo Starý at the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague

Chronology of Employment

since 2009

Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Dr. Ivo Starý group, current position: Postdoctoral Fellow

Selected papers

Synthesis of Long Oxahelicenes by Polycyclization in a Flow Reactor
Synthesis of Long Oxahelicenes by Polycyclization in a Flow Reactor
Angewandte Chemie International Edition 56 (21): 5839-5843 (2017)
A series of oxahelicenes composed of ortho/meta‐annulated benzene/pyridine and 2H‐pyran rings were synthesized on the basis of the cobalt(I)‐mediated (or rhodium(I)‐ or nickel(0)‐mediated) double, triple, or quadruple [2+2+2] cycloisomerization of branched aromatic hexa‐, nona‐, or dodecaynes, thus allowing the construction of 6, 9, or 12 rings in a single operation. The use of a flow reactor was found to be beneficial for the multicyclization reactions. The stereogenic centers present in some of the oligoynes steered the helical folding in such a way that the final oxa[9]‐, [13]‐, [17]‐ and [19]helicenes were obtained in both enantiomerically and diastereomerically pure form. Specifically, the oxa[19]helicenes beat the current record in the length of a helicene backbone. Single‐molecule conductivity was studied by the mechanically controllable break‐junction method with a pyridooxa[9]helicene.

Latest publications

Synthesis of Racemic, Diastereopure, and Enantiopure Carba- or Oxa[5]-, [6]-, [7]-, and -[19]helicene (Di)thiol Derivatives
Journal of Organic Chemistry 85 (1): 248-276 (2020)
Large Converse Piezoelectric Effect Measured on a Single Molecule on a Metallic Surface
Journal of the American Chemical Society 140 (3): 940-946 (2018)
Oxahelicene NHC ligands in the asymmetric synthesis of nonracemic helicenes
Chemical Communications 53 (31): 4370-4373 (2017)