CS
Aleš Marek

Aleš Marek

mail ales.marekinvalid-email-name@invalid-email-domainuochb.cas.cz
phone +420 731 194 175
phone +420 220 183 395
Group leader
Synthesis of Radiolabeled Compounds
Aleš Marek Group

Profile

Labeling of organic molecules by 3H, 14C and 125I. Ultra-small scale synthesis of labeled material (μg-mg). Low scale (mg) solid state peptide synthesis lebeled by (radio)isotopes 2H/3H/13C/18O/125I or photosensitive tag. Structural characterization and isotopic enrichment determination; MS, 3H NMR. Oligonucleotide synthesis using 15N labeled building blocks (200 nmol, stepwise in syringes). Research on reduction using noble-metal-free catalysis by Frustrated Lewis Pairs (FLP).

Radiation safety officer for IOCB campus.

Radiation safety training of newcomers and annual safety training for radiation exposed workers A and B.

Education
2009

Ph.D. in Organic Chemistry under Assistant Professor Jiří Kulhánek, Faculty of Chemical Technology, University of Pardubice.

2006

Ing. in Organic Chemistry, thesis supervisor Assistant Professor Jiří Kulhánek, Faculty of Chemical Technology, University of Pardubice.

Appointments
2006

Scholarship, supervisor Prof. Peter Eilbracht, Department of Organic Chemistry, Universität Dortmund, Germany.

2011-2012

Scholarship of IAEA, supervisor Martin H.F. Pedersen, Ph.D., Riso DTU Nutech, The Hevesy Laboratory, Denmark.

2012-2013

Postdoctoral fellowship, supervisor Prof. Frank Turecek, Department of Chemistry, University of Washington, Seattle, WA, USA.

Load more
Other sources
arrow
arrow
arrow
arrow
All publications

Latest publications

The DNA Radical Code. Resolution of Identity in Dissociations of Trinucleotide Codon Cation Radicals in the Gas Phase
J. Wan B. Brož Y. Liu S. R. Huang A. Marek F. Tureček
Journal of the American Society for Mass Spectrometry 34 (2): 304–319 (2023)
Go to the publication arrow
Resolution of Identity in Gas-Phase Dissociations of Mono- and Diprotonated DNA Trinucleotide Codons by 15N-Labeling and Computational Structure Analysis
J. Wan B. Brož L. Liu S. R. Huang A. Marek F. Tureček
Journal of the American Society for Mass Spectrometry 33 (10): 1936–1950 (2022)
Go to the publication arrow
Low-scale syringe-made synthesis of 15N-labeled oligonucleotides
B. Brož F. Tureček A. Marek
Journal of Labelled Compounds and Radiopharmaceuticals 65 (12): 309–314 (2022)
Go to the publication arrow
Tritium hydrogen-isotope exchange with electron-poor tertiary benzenesulfonamide moiety; application in late-stage labeling of T0901317
T. Yongsong B. Brož F. Tureček A. Marek
Journal of Labelled Compounds and Radiopharmaceuticals 65 (2): 36–44 (2022)
Go to the publication arrow