Gabriel Birkuš

All publications

Latest publications

Conformationally Constrained Phosphonate Backbone Linkages Enhance CpG Oligonucleotide Activation of Toll-Like Receptor 9

I. Kóšiová I. Štěpánek O. Šimák O. Kostov M. Petrová O. Páv D. Rejman R. Liboska M. Buděšínský Š. Rosenbergová G. Birkuš I. Rosenberg

ACS Pharmacology & Translational Science 9 (8): 2324–2332 (2026)

Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function

M. Klíma M. Dejmek V. Duchoslav A. Eisenreichová M. Šála K. Chalupský D. Chalupská B. Novotná G. Birkuš R. Nencka E. Bouřa

Structure 32 (4): 433–439.e4 (2024)

Synthesis of Original Cyclic Dinucleotide Analogues Using the Sulfo-click Reaction

R. Amador J. Vasseur G. Birkuš E. Bignon A. Monari G. Clavé M. Smietana

Organic Letters 260 (4): 819–823 (2024)

Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy

M. Dejmek A. Brázdová T. Otava M. Pimková Polidarová M. Klíma M. Smola Z. Vavřina M. Buděšínský M. Dračínský R. Liboska E. Bouřa G. Birkuš R. Nencka

European Journal of Medicinal Chemistry 259: 115685 (2023)