Gabriel Birkuš

Všechny publikace

Nejnovější publikace

Synthesis of phosphonate derivatives of 2′-deoxy-2′-fluorotetradialdose D-nucleosides and tetradialdose D-nucleosides

T. Lášek J. Dobiaš M. Buděšínský J. Kozák B. Lapuníková I. Rosenberg G. Birkuš O. Páv

Tetrahedron 89: Early View (2021)

Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3′,3′-c-Di(2′F,2′dAMP)

M. Pimková Polidarová P. Břehová M. M. Kaiser M. Smola M. Dračínský J. Smith A. Marek M. Dejmek M. Šála O. Gutten L. Rulíšek B. Novotná A. Brázdová Z. Janeba R. Nencka E. Bouřa O. Páv G. Birkuš

Journal of Medicinal Chemistry 64 (11): 7596–7616 (2021)

Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein

M. Smola O. Gutten M. Dejmek M. Kožíšek T. Evangelidis Z. Aliakbar Tehrani B. Novotná R. Nencka G. Birkuš L. Rulíšek E. Bouřa

Angewandte Chemie International Edition 60 (18): 10172-10178 (2021)

Protein–Ligand Interactions in the STING Binding Site Probed by Rationally Designed Single-Point Mutations: Experiment and Theory

Z. Vavřina O. Gutten M. Smola M. Zavřel Z. Aliakbar Tehrani V. Charvát M. Kožíšek E. Bouřa G. Birkuš L. Rulíšek

Biochemistry 60 (8): 607–620 (2021)